Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil (Q28362294)

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Language	Label	Description	Also known as
English	Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil	scientific article

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scholarly article

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title

Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil (English)

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author name string

R Hyland

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1

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E G Roe

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2

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B C Jones

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3

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D A Smith

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4

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language of work or name

English

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publication date

March 2001

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published in

British Journal of Clinical Pharmacology

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volume

51

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issue

3

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page(s)

239-48

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cites work

Protein measurement with the Folin phenol reagent

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20 March 2017

In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions

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20 March 2017

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

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20 March 2017

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

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Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir

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Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

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Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate

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Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

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2 June 2018

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

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Midazolam alpha-hydroxylation by human liver microsomes in vitro: inhibition by calcium channel blockers, itraconazole and ketoconazole

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Interaction of sildenafil and indinavir when co-administered to HIV-positive patients

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Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

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Oxidation of quinidine by human liver cytochrome P-450

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High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

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Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats

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Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes

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reference URL

https://pubmed.ncbi.nlm.nih.gov/11298070

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12 December 2020

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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PubMed

reference URL

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12 December 2020

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Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11298070

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sildenafil, a novel effective oral therapy for male erectile dysfunction

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11298070

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam

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PubMed

reference URL

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retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11298070

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11298070

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1046/J.1365-2125.2001.00318.X

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3955322

OpenCitations bibliographic resource ID

3955322

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3955322

PMC publication ID

2015027

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3955322

PubMed publication ID

11298070

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3955322

ResearchGate publication ID

12036278

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