Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics (Q28366642)

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English	Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics	scientific article

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5 December 2019

Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics (English)

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5 December 2019

transmembrane protein

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Matthew D. Krasowski

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5 December 2019

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K Nishikawa

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5 December 2019

N Nikolaeva

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5 December 2019

A Lin

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N L Harrison

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1 December 2001

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Neuropharmacology

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5 December 2019

952-964

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5 December 2019

Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures

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20 March 2017

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations

1 reference

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Structures of the flavocytochrome p-cresol methylhydroxylase and its enzyme-substrate complex: gated substrate entry and proton relays support the proposed catalytic mechanism

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20 March 2017

General anaesthetic actions on ligand-gated ion channels

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20 March 2017

Structural basis for the inhibition of firefly luciferase by a general anesthetic

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The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis

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Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity

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Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]

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20 March 2017

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors

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A simple method for displaying the hydropathic character of a protein

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20 March 2017

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

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20 March 2017

Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits

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20 March 2017

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina

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20 March 2017

GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs

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20 March 2017

Prediction of protein antigenic determinants from amino acid sequences

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7 April 2017

General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility

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29 September 2017

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

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29 September 2017

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol

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29 September 2017

Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency

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29 September 2017

Chemical properties of alcohols and their protein binding sites.

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29 September 2017

Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery

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29 September 2017

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

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29 September 2017

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

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29 September 2017

Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation

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29 September 2017

Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes

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29 September 2017

Regio- and stereospecific conversion of 4-alkylphenols by the covalent flavoprotein vanillyl-alcohol oxidase

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29 September 2017

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

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29 September 2017

Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.

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29 September 2017

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

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29 September 2017

Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics

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Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein

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29 September 2017

Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication

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29 September 2017

Molecular and cellular mechanisms of general anaesthesia

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29 September 2017

Is there a general anesthesia receptor

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29 September 2017

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

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29 September 2017

The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.

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2 June 2018

Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.

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2 June 2018

Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat.

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2 June 2018

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

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p-Cresol methylhydroxylase. Assay and general properties

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2 June 2018

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2 June 2018

Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

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Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

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Volume changes on protein folding.

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Modified substrate specificity of L-hydroxyisocaproate dehydrogenase derived from structure-based protein engineering

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Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in Xenopus oocytes

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7 January 2021

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