Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling (Q28303564)

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Natalia Raess

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Lan Cheng

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Eliane J Muller

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Glenn L Radice

Molecular and Cellular Biology

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language of work or name

English

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publication date

March 2011

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published in

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volume

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issue

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page(s)

1134-44

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cites work

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A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy

20 March 2017

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Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

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20 March 2017

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20 March 2017

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Protein kinase cascades in the regulation of cardiac hypertrophy

20 March 2017

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Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure

20 March 2017

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Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line

20 March 2017

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Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

20 March 2017

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Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

20 March 2017

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Embryonic heart and skin defects in mice lacking plakoglobin

20 March 2017

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Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart

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Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

7 April 2017

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7 April 2017

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Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatment

29 September 2017

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Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy

29 September 2017

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Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

29 September 2017

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Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy

29 September 2017

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Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects

29 September 2017

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N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.

29 September 2017

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Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction.

29 September 2017

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Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

29 September 2017

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Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin

29 September 2017

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Plakoglobin and beta-catenin: protein interactions, regulation and biological roles

29 September 2017

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Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).

29 September 2017

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Wnt-1 regulation of connexin43 in cardiac myocytes

29 September 2017

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Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro

29 September 2017

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Cardiac abnormalities in familial palmoplantar keratosis

29 September 2017

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Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.

29 September 2017

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Crucial role of interleukin-6 in the development of norepinephrine-induced left ventricular remodeling in mice.

27 November 2018

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A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy

27 November 2018

1 reference

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Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3067899

Cardiac-Specific Loss of N-Cadherin Leads to Alteration in Connexins With Conduction Slowing and Arrhythmogenesis

27 November 2018

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Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

27 November 2018

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Arrhythmogenic right ventricular cardiomyopathy

27 November 2018

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12 December 2020

Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling

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12 December 2020

Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways

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12 December 2020

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels

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12 December 2020

Structural and molecular pathology of the heart in Carvajal syndrome

1 reference

12 December 2020

Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart

1 reference

12 December 2020

Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease)

1 reference

12 December 2020

Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes

1 reference

12 December 2020