Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease (Q28292922)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15540952%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease (English)

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5 January 2020

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Pierluigi Caboni

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5 January 2020

Todd B Sherer

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5 January 2020

Nanjing Zhang

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5 January 2020

Georgia Taylor

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5 January 2020

Hye Me Na

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5 January 2020

language of work or name

English

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publication date

1 November 2004

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Chemical Research in Toxicology

5 January 2020

published in

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5 January 2020

volume

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5 January 2020

issue

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5 January 2020

page(s)

1540-1548

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Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents

5 January 2020

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Environment, mitochondria, and Parkinson's disease

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Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities

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An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

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Quantitative Autoradiography of Dihydrorotenone Binding to Complex I of the Electron Transport Chain

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In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone.

20 August 2024

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Distribution of rotenone and deguelin in Tephrosia vogelii and separation of rotenoid-rich fractions

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The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.

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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase

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Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

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Cancer chemopreventive activity of rotenoids from Derris trifoliata

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Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase

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Discovery of cancer preventive agents from natural products: from plants to prevention

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

20 August 2024

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Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest

20 August 2024

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The rotenone model of Parkinson's disease: genes, environment and mitochondria

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Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

20 August 2024

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Selective microglial activation in the rat rotenone model of Parkinson's disease

20 August 2024

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Synthesis and biological evaluation in mice of (2-[11C]methoxy)-6',7'-dihydrorotenol, a second generation rotenoid for marking mitochondrial complex I activity.

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The insecticide target in the PSST subunit of complex I.

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Uncoupling action of 2,4-dinitrophenols, 2-trifluoromethylbenzimidazoles and certain other pesticide chemicals upon mitochondria from different sources and its relation to toxicity

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Increased striatal dopamine turnover following acute administration of rotenone to mice

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Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats

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Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

20 August 2024

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Response of hepatic microsomal mixed-function oxidases to various types of insecticide chemical synergists administered to mice

20 August 2024

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Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

20 August 2024

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NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells

20 August 2024

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

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