PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination (Q28291192)

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15 January 2020

title

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination (English)

1 reference

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15 January 2020

main subject

protein ubiquitination

1 reference

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15 January 2020

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15 January 2020

Takeshi Senga

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15 January 2020

Umasundari Sivaprasad

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15 January 2020

Wenge Zhu

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15 January 2020

Jong Hoon Park

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15 January 2020

Emily E Arias

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15 January 2020

language of work or name

English

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publication date

9 January 2006

1 reference

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

281

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issue

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15 January 2020

page(s)

6246-6252

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DNA replication in eukaryotic cells

15 January 2020

cites work

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

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The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

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A p53-dependent checkpoint pathway prevents rereplication

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Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

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Loss of Geminin induces rereplication in the presence of functional p53

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

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Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

21 January 2018

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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

21 January 2018

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

21 January 2018

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

21 January 2018

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Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex

21 January 2018

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

21 January 2018

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

21 January 2018

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CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

21 January 2018

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo

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Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

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N-terminal ubiquitination: more protein substrates join in.

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Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

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N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

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Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination

21 January 2018

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Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation

21 January 2018

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p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases

21 January 2018

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

21 January 2018

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21 January 2018

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A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

21 January 2018

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Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M512705200

2 references

Consolidated OpenCitations Corpus – April 2017

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15 January 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

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