Retinoid X receptors: X-ploring their (patho)physiological functions (Q28299087)

9 April 2017

L Nagy

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A Szanto

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9 April 2017

V Narkar

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9 April 2017

Q Shen

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9 April 2017

I P Uray

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9 April 2017

P J A Davies

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9 April 2017

language of work or name

English

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publication date

December 2004

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Cell Death & Differentiation

9 April 2017

published in

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9 April 2017

volume

11 Suppl 2

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1 reference

9 April 2017

page(s)

S126-43

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S126-S143

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A human retinoic acid receptor which belongs to the family of nuclear receptors

9 April 2017

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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

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The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

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Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.

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7 January 2021

Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice

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7 January 2021

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

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7 January 2021

Cloning of the human glucocorticoid receptor cDNA

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7 January 2021

Identification of human glucocorticoid receptor complementary DNA clones by epitope selection

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7 January 2021

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Origins and evolutionary diversification of the nuclear receptor superfamily

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Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

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Retinoic acid X receptor in the diploblast, Tripedalia cystophora

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A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue

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7 January 2021

Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor.

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7 January 2021

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

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7 January 2021

The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation

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7 January 2021

The nuclear receptor superfamily: the second decade

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Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factors

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Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

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7 January 2021

The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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7 January 2021

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7 January 2021

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

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7 January 2021

Mechanism of corepressor binding and release from nuclear hormone receptors.

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7 January 2021

Molecular determinants of nuclear receptor-corepressor interaction

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7 January 2021

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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7 January 2021

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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7 January 2021

Mechanism of the nuclear receptor molecular switch

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7 January 2021

A novel role for helix 12 of retinoid X receptor in regulating repression

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7 January 2021

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

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7 January 2021

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

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7 January 2021

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

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7 January 2021

Phytanic acid is a retinoid X receptor ligand

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7 January 2021

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

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7 January 2021

Retinoid-X receptor signalling in the developing spinal cord

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7 January 2021

Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos

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7 January 2021

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

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7 January 2021

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.

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7 January 2021

RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.

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7 January 2021

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

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7 January 2021

RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses

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7 January 2021

Function of retinoic acid receptor gamma in the mouse

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7 January 2021

Retinoids in embryonal development

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7 January 2021

Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse.

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7 January 2021

PPAR gamma is required for placental, cardiac, and adipose tissue development

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7 January 2021

Retinoid X receptors are essential for early mouse development and placentogenesis

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7 January 2021

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7 January 2021

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

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PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

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7 January 2021

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

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7 January 2021

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

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7 January 2021

Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance

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7 January 2021

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

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7 January 2021

Chimeric analysis of retinoic acid receptor function during cardiac looping

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7 January 2021

Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid

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7 January 2021

Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation

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7 January 2021

Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure

1 reference

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7 January 2021

Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response

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7 January 2021

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

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7 January 2021

Coordinately regulated expression of FAT/CD36 and FACS1 in rat skeletal muscle

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7 January 2021

Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet

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7 January 2021

Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle

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7 January 2021

Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle

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7 January 2021

Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis

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7 January 2021

Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects

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7 January 2021

Role of tyrosyl and arginyl residues in rat liver microsomal stearylcoenzyme A desaturase

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7 January 2021

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

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7 January 2021

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

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7 January 2021

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

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7 January 2021

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

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7 January 2021

Insulin binding and glucose uptake differences in rodent skeletal muscles

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7 January 2021

Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists

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7 January 2021

Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats

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7 January 2021

Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L6 myotubes

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7 January 2021

The human uncoupling protein-3 gene promoter requires MyoD and is induced by retinoic acid in muscle cells

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7 January 2021

Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells

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7 January 2021

A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle

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7 January 2021

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Human skeletal muscle PPARalpha expression correlates with fat metabolism gene expression but not BMI or insulin sensitivity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

PPAR(gamma) and glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

The hormone resistin links obesity to diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization

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7 January 2021

Troglitazone action is independent of adipose tissue

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Troglitazone induces GLUT4 translocation in L6 myotubes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Signaling pathways in insulin action: molecular targets of insulin resistance

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069

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7 January 2021

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

1 reference

7 January 2021

Atherosclerosis. the road ahead

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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7 January 2021

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

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7 January 2021

Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

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7 January 2021

Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans.

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7 January 2021

Cerebrotendinous Xanthomatosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.

1 reference

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7 January 2021

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

1 reference

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7 January 2021

The role of retinoids and retinoic acid receptors in normal hematopoiesis

1 reference

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7 January 2021

Expression of Retinoid X Receptor alpha is increased upon monocytic cell differentiation

1 reference

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7 January 2021

Retinoid-induced apoptosis in normal and neoplastic tissues

1 reference

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7 January 2021

Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Activation of retinoid X receptors induces apoptosis in HL-60 cell lines

1 reference

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7 January 2021

Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

1 reference

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7 January 2021

Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Decryption of the retinoid death code in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Inhibition of trans-Retinoic Acid-Resistant Human Breast Cancer Cell Growth by Retinoid X Receptor-Selective Retinoids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401533

7 January 2021

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401533

2 references

9 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3284145

Dimensions Publication ID

1004065710

0 references

OpenCitations bibliographic resource ID

3284145

1 reference