A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation (Q28269042)

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28 February 2020

title

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation (English)

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28 February 2020

0 references

1 reference

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28 February 2020

Daniel Iglesias-Serret

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28 February 2020

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28 February 2020

author name string

Cristina Moncunill-Massaguer

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28 February 2020

Alba Pérez-Perarnau

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28 February 2020

Claudia Mariela Palmeri

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28 February 2020

Sonia Núñez-Vázquez

1 reference

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28 February 2020

Ana M Cosialls

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28 February 2020

Diana M González-Gironès

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28 February 2020

Helena Pomares

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28 February 2020

Anne Korwitz

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28 February 2020

Sara Preciado

1 reference

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28 February 2020

Fernando Albericio

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28 February 2020

Rodolfo Lavilla

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28 February 2020

Gabriel Pons

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28 February 2020

Thomas Langer

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28 February 2020

language of work or name

English

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publication date

1 December 2015

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28 February 2020

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28 February 2020

volume

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28 February 2020

issue

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28 February 2020

page(s)

41750-41765

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A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

28 February 2020

cites work

1 reference

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Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria

20 March 2017

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The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

20 March 2017

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Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway

20 March 2017

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The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2

20 March 2017

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Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

20 March 2017

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20 March 2017

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Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

20 March 2017

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Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

20 March 2017

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Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

20 March 2017

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Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways

20 March 2017

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Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

20 March 2017

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Prohibitin: a potential target for new therapeutics

20 March 2017

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Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo

20 March 2017

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

20 March 2017

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Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin

20 March 2017

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

20 March 2017

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

20 March 2017

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Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins.

20 March 2017

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

20 March 2017

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Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

20 March 2017

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Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

20 March 2017

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Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

20 March 2017

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20 March 2017

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Mitochondrial membrane permeabilization in cell death

20 March 2017

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Mitochondria and cell death: outer membrane permeabilization and beyond

7 April 2017

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7 April 2017

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A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

7 April 2017

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Prohibitin protects proximal tubule epithelial cells against oxidative injury through mitochondrial pathways

7 April 2017

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Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells

29 September 2017

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Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

29 September 2017

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Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

29 September 2017

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MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis

29 September 2017

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miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Prohibitin 1 modulates mitochondrial function of Stat3.

29 September 2017

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Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis

29 September 2017

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Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

29 September 2017

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Many players in BCL-2 family affairs

29 September 2017

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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

29 September 2017

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Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease

29 September 2017

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Prohibitin (PHB) inhibits apoptosis in rat granulosa cells (GCs) through the extracellular signal-regulated kinase 1/2 (ERK1/2) and the Bcl family of proteins

29 September 2017

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MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin

29 September 2017

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Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

29 September 2017

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Prohibitin ligands in cell death and survival: mode of action and therapeutic potential

29 September 2017

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Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells

29 September 2017

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Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration

29 September 2017

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Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens

29 September 2017

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Mitochondrial-nuclear communication by prohibitin shuttling under oxidative stress

29 September 2017

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Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

29 September 2017

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Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

29 September 2017

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The role and therapeutic potential of prohibitin in disease

29 September 2017

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Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice

29 September 2017

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Prohibitins Are Required for Cancer Cell Proliferation and Adhesion

29 September 2017

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The role of prohibitin in cell signaling.

29 September 2017

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Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

29 September 2017

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Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications

29 September 2017

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Prohibitins and the functional compartmentalization of mitochondrial membranes.

29 September 2017

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Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

29 September 2017

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Prohibitin and mitochondrial biology

29 September 2017

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Noxa: at the tip of the balance between life and death.

29 September 2017

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Bim and Bmf in tissue homeostasis and malignant disease

29 September 2017

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Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein

29 September 2017

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MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin

29 September 2017

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Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization

29 September 2017

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Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.

29 September 2017

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Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

29 September 2017

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Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

29 September 2017

1 reference

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A repressive role for prohibitin in estrogen signaling.

29 September 2017

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The SPFH domain-containing proteins: more than lipid raft markers

29 September 2017

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Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration

29 September 2017

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Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways

29 September 2017

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Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis

29 September 2017

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Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes

29 September 2017

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Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities

29 September 2017

1 reference

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Reduction of prohibitin expression contributes to left ventricular hypertrophy via enhancement of mitochondrial reactive oxygen species formation in spontaneous hypertensive rats

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

Prohibitin is associated with antioxidative protection in hypoxia/reoxygenation-induced renal tubular epithelial cell injury

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

Prohibitin protects against oxidative stress in intestinal epithelial cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747186

Flavaglines as potent anticancer and cytoprotective agents

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26497683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26497683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.6154

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497683%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497683%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

26497683

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497683%20AND%20SRC:MED&resulttype=core&format=json