Alpha-synuclein and tau: teammates in neurodegeneration? (Q28250508)

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Elisabeth L Moussaud-Lamodière

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Marion Delenclos

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Pamela J McLean

Molecular Neurodegeneration

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language of work or name

English

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publication date

29 October 2014

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25 April 2019

11 December 2019

19 December 2019

20 December 2019

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25 April 2019

11 December 2019

19 December 2019

20 December 2019

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Creative Commons Attribution

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25 April 2019

11 December 2019

19 December 2019

20 December 2019

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on focus list of Wikimedia project

ScienceSource

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cites work

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Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262 and Destabilize Microtubule Cytoskeleton in Vitro

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

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alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton

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GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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alpha-Synuclein locus triplication causes Parkinson's disease

20 March 2017

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Tubulin seeds alpha-synuclein fibril formation

20 March 2017

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A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study

20 March 2017

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14-3-3zeta is an effector of tau protein phosphorylation

20 March 2017

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alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

20 March 2017

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

20 March 2017

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α-Synuclein in Lewy bodies

20 March 2017

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

20 March 2017

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Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

20 March 2017

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Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism

20 March 2017

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

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Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

7 April 2017

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

7 April 2017

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

7 April 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

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A Drosophila model of Parkinson's disease

7 April 2017

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Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.

7 April 2017

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Association studies of sporadic Parkinson's disease in the genomic era.

29 September 2017

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Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

29 September 2017

1 reference

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Drosophila melanogaster as a model organism for Alzheimer's disease

29 September 2017

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Update on novel familial forms of Parkinson's disease and multiple system atrophy

29 September 2017

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Transmission of multiple system atrophy prions to transgenic mice

29 September 2017

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Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

29 September 2017

1 reference

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Mouse models of cognitive deficits due to alpha-synuclein pathology

29 September 2017

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α-Synuclein oligomers impair neuronal microtubule-kinesin interplay.

29 September 2017

1 reference

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

29 September 2017

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Tau pathology and neurodegeneration

29 September 2017

1 reference

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Prion-like spreading of pathological α-synuclein in brain

29 September 2017

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

29 September 2017

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Cerebrospinal fluid biomarkers in Parkinson disease

29 September 2017

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α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

29 September 2017

1 reference

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A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration

29 September 2017

1 reference

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Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone

29 September 2017

1 reference

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Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

29 September 2017

1 reference

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

29 September 2017

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

29 September 2017

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Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

29 September 2017

1 reference

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Looking for novel functions of tau.

29 September 2017

1 reference

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The neuropathology of genetic Parkinson's disease

29 September 2017

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Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways

29 September 2017

1 reference

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Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease

29 September 2017

1 reference

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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.

29 September 2017

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Neurotoxin-based models of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Induction of Intracellular Tau Aggregation Is Promoted by α-Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

29 September 2017

1 reference

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Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tauopathic Changes in the Striatum of A53T α-Synuclein Mutant Mouse Model of Parkinson's Disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Neuropathological findings of PSP in the elderly without clinical PSP: Possible incidental PSP?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

MAPT H1 haplotype is a risk factor for essential tremor and multiple system atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Genetic animal models of Parkinson's disease

29 September 2017

1 reference

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Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Cognitive impairment and dementia in patients with Parkinson disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

The role of tau in neurodegeneration

29 September 2017

1 reference

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Propagation of tau misfolding from the outside to the inside of a cell.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

29 September 2017

1 reference

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Tau exon 10 alternative splicing and tauopathies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

CHIP targets toxic alpha-Synuclein oligomers for degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Parkinson's disease--Part 2: Treatment of motor symptoms.

29 September 2017

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Parkinson's disease--Part 1: Pathophysiology, symptoms, burden, diagnosis, and assessment.

29 September 2017

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Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient

29 September 2017

1 reference

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Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease

29 September 2017

1 reference

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Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

29 September 2017

1 reference

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An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

29 September 2017

1 reference

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Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

A systematic review of prevalence studies of dementia in Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Regulation of tau isoform expression and dementia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

A distinct familial presenile dementia with a novel missense mutation in the tau gene

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

2 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Cognitive status correlates with neuropathologic stage in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Substantia nigra tangles are related to gait impairment in older persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Proteomic identification of novel proteins in cortical lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Association of an extended haplotype in the tau gene with progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Absence of alpha-synuclein pathology in postencephalitic parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

The role of MAPT sequence variation in mechanisms of disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Sequence determinants regulating fibrillation of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Proteasomal degradation of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

SNCA,MAPT, andGSK3Bin Parkinson disease: a gene-gene interaction study

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Interaction of ?-synuclein and tau genotypes in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-9-43

Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Progressive supranuclear palsy and Parkinson's disease in a family with a new mutation in the tau gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Accumulation of phosphorylated alpha-synuclein in aging human brain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230508

Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease

27 November 2018

1 reference

12 December 2020

Genetics: The MAPT locus-a genetic paradigm in disease susceptibility

1 reference

12 December 2020

Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy

1 reference

12 December 2020

Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene

1 reference

12 December 2020

Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype

1 reference

12 December 2020

Identifiers

DOI

10.1186/1750-1326-9-43

1 reference

Dimensions Publication ID

1049166689

0 references

1 reference

1 reference

PubMed publication ID

25352339

1 reference