Prions as adaptive conduits of memory and inheritance (Q28254236)

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog

21 April 2017

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Amyloid aggregates of the HET-s prion protein are infectious

21 April 2017

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Protein folding and misfolding

21 April 2017

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A yeast prion provides a mechanism for genetic variation and phenotypic diversity

21 April 2017

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Sequencing and comparison of yeast species to identify genes and regulatory elements

21 April 2017

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21 April 2017

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Evolvability is a selectable trait

21 April 2017

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The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae.

21 April 2017

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Evolutionary capacitance as a general feature of complex gene networks

21 April 2017

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Functional discovery via a compendium of expression profiles

21 April 2017

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A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions

21 April 2017

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A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes

21 April 2017

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A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia

21 April 2017

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The persistence of long-term memory: a molecular approach to self-sustaining changes in learning-induced synaptic growth

21 April 2017

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The molecular basis of CaMKII function in synaptic and behavioural memory

21 April 2017

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Emergent properties of networks of biological signaling pathways

21 April 2017

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Translational control by CPEB: a means to the end

21 April 2017

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The SAM domain of polyhomeotic forms a helical polymer

21 April 2017

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Stress granule assembly is mediated by prion-like aggregation of TIA-1

21 April 2017

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A self-replicating peptide

21 April 2017

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Protein disaggregation mediated by heat-shock protein Hsp104.

21 April 2017

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Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding

21 April 2017

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Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

21 April 2017

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Mechanism of prion propagation: amyloid growth occurs by monomer addition

21 April 2017

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From microbes to prions the final proof of the prion hypothesis

21 April 2017

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 April 2017

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Eight prion strains have PrP(Sc) molecules with different conformations

21 April 2017

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Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 April 2017

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 April 2017

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Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

21 April 2017

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Novel proteinaceous infectious particles cause scrapie

31 March 2020

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[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae

31 March 2020

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A neuronal isoform of the aplysia CPEB has prion-like properties

31 March 2020

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Prions as protein-based genetic elements

31 March 2020

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Emerging principles of conformation-based prion inheritance

31 March 2020

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Does the agent of scrapie replicate without nucleic acid?

31 March 2020

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Self-replication and scrapie

31 March 2020

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Scrapie prions aggregate to form amyloid-like birefringent rods

31 March 2020

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Normal host prion protein necessary for scrapie-induced neurotoxicity

31 March 2020

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Ψ, A cytoplasmic suppressor of super-suppressor in yeast

31 March 2020

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Rnq1: an epigenetic modifier of protein function in yeast

31 March 2020

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Molecular basis of a yeast prion species barrier

31 March 2020

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Dissection and design of yeast prions

31 March 2020

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Pathway complexity of prion protein assembly into amyloid

31 March 2020

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Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.

31 March 2020

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Prion domain initiation of amyloid formation in vitro from native Ure2p

31 March 2020

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Support for the prion hypothesis for inheritance of a phenotypic trait in yeast

31 March 2020

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Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor

31 March 2020

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Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells

31 March 2020

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Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserina

31 March 2020

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Prion filament networks in [URE3] cells of Saccharomyces cerevisiae

31 March 2020

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Analysis of yeast prion aggregates with amyloid-staining compound in vivo

31 March 2020

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Yeast [PSI+] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104

31 March 2020

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Protein-only transmission of three yeast prion strains

31 March 2020

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Nucleated conformational conversion and the replication of conformational information by a prion determinant

31 March 2020

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Conformational variations in an infectious protein determine prion strain differences

31 March 2020

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Synthetic mammalian prions

31 March 2020

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Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein

31 March 2020

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31 March 2020

A transforming principle

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A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice

31 March 2020

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Strain-specified characteristics of mouse synthetic prions

31 March 2020

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Transmissible spongiform encephalopathies: prion proof in progress

31 March 2020

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Evidence for and against the transmissibility of Alzheimer disease

31 March 2020

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De novo amyloid proteins from designed combinatorial libraries

31 March 2020

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Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein

31 March 2020

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Yeast [PSI+] "prions" that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state

31 March 2020

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Conservation of the prion properties of Ure2p through evolution

31 March 2020

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Mad cows meet psi-chotic yeast: the expansion of the prion hypothesis

31 March 2020

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Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis

31 March 2020

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The hydrophobin EAS is largely unstructured in solution and functions by forming amyloid-like structures

31 March 2020

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Role of Escherichia coli curli operons in directing amyloid fiber formation

31 March 2020

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Tissue-type plasminogen activator is a multiligand cross-beta structure receptor

31 March 2020

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Do antiangiogenic protein fragments have amyloid properties?

31 March 2020

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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

31 March 2020

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Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

31 March 2020

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[URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p

31 March 2020

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The role of Sis1 in the maintenance of the [RNQ+] prion

31 March 2020

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Specificity of class II Hsp40 Sis1 in maintenance of yeast prion [RNQ+].

31 March 2020

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

31 March 2020

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siRNA relieves chronic neuropathic pain

31 March 2020

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

31 March 2020

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Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells.

31 March 2020

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Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion

31 March 2020

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Nonsense-mediated decay mutants do not affect programmed -1 frameshifting

31 March 2020

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Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

31 March 2020

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Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism

31 March 2020

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THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION.

31 March 2020

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31 March 2020

Evolving evolvability

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Evolution: the evolvability enigma

31 March 2020

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THE EVOLUTION OF THE EVOLVABILITY PROPERTIES OF THE YEAST PRION [PSI + ]

31 March 2020

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Prion protein gene polymorphisms in Saccharomyces cerevisiae

31 March 2020

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. . . but yeast prion offers clues about evolution

31 March 2020

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A small reservoir of disabled ORFs in the yeast genome and its implications for the dynamics of proteome evolution.

31 March 2020

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Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae

31 March 2020

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Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina

31 March 2020

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Prions affect the appearance of other prions: the story of [PIN(+)].

31 March 2020

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Interactions among prions and prion "strains" in yeast

31 March 2020

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Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

31 March 2020

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Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

31 March 2020

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Oligopeptide-repeat expansions modulate ‘protein-only’ inheritance in yeast

31 March 2020

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Scrambled prion domains form prions and amyloid

31 March 2020

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Conformational constraints for amyloid fibrillation: the importance of being unfolded

31 March 2020

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Positive autoregulation of the myogenic determination gene MyoD1.

31 March 2020

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The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types

31 March 2020

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Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD.

31 March 2020

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Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus

31 March 2020

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Creating a protein-based element of inheritance

31 March 2020

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Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein

31 March 2020

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Derepression by depolymerization; structural insights into the regulation of Yan by Mae.

31 March 2020

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The SWI/SNF complex--chromatin and cancer.

31 March 2020

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Whole-genome expression analysis of snf/swi mutants of Saccharomyces cerevisiae

31 March 2020

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Heritable activity: a prion that propagates by covalent autoactivation

31 March 2020

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A non-chromosomal factor allows viability of Schizosaccharomyces pombe lacking the essential chaperone calnexin

31 March 2020

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Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]

31 March 2020

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Specificity of prion assembly in vivo. [PSI+] and [PIN+] form separate structures in yeast

31 March 2020

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Induction of distinct [URE3] yeast prion strains

31 March 2020

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Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.

31 March 2020

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Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro

31 March 2020

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Dependence and independence of [PSI(+)] and [PIN(+)]: a two-prion system in yeast?

31 March 2020

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Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy

31 March 2020

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Transmissibility of systemic amyloidosis by a prion-like mechanism

31 March 2020

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Induction of protein conformational change in mouse senile amyloidosis

31 March 2020

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Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

31 March 2020

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Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins

31 March 2020

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Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

31 March 2020

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Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition

31 March 2020

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Quantifying the kinetic parameters of prion replication.

31 March 2020

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Emergence of symbiosis in peptide self-replication through a hypercyclic network

31 March 2020

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

31 March 2020

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Separation of scrapie prion infectivity from PrP amyloid polymers

31 March 2020

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

31 March 2020

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Mechanism of prion loss after Hsp104 inactivation in yeast

31 March 2020

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The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.

31 March 2020

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The mechanisms of [URE3] prion elimination demonstrate that large aggregates of Ure2p are dead-end products.

31 March 2020

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Hsp104 binds to yeast Sup35 prion fiber but needs other factor(s) to sever it.

31 March 2020

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The elimination of the yeast [PSI+] prion by guanidine hydrochloride is the result of Hsp104 inactivation

31 March 2020

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Navigating the ClpB channel to solution.

31 March 2020

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Protein-only inheritance in yeast: something to get [PSI+]-ched about

31 March 2020

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

31 March 2020

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An mRNA surveillance mechanism that eliminates transcripts lacking termination codons

31 March 2020

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

31 March 2020

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In vitro generation of infectious scrapie prions.

31 March 2020

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Improvement of nitrogen assimilation and fermentation kinetics under enological conditions by derepression of alternative nitrogen-assimilatory pathways in an industrial Saccharomyces cerevisiae strain.

31 March 2020

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