Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway. (Q28243993)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785216%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway (English)

1 reference

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8 February 2020

main subject

spinal muscular atrophy

1 reference

1 reference

1 reference

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8 February 2020

Faraz Farooq

1 reference

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8 February 2020

Francisco Abadía Molina

1 reference

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8 February 2020

Jeremiah Hadwen

1 reference

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8 February 2020

Duncan MacKenzie

1 reference

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8 February 2020

Luke Witherspoon

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8 February 2020

Matthew Osmond

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8 February 2020

Alex MacKenzie

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8 February 2020

language of work or name

English

0 references

publication date

25 July 2011

1 reference

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Journal of Clinical Investigation

8 February 2020

published in

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8 February 2020

volume

121

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8 February 2020

issue

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8 February 2020

page(s)

3042-3050

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Cardiac defects contribute to the pathology of spinal muscular atrophy models

8 February 2020

cites work

1 reference

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Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice

20 March 2017

1 reference

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Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

20 March 2017

1 reference

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SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

20 March 2017

1 reference

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Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice

20 March 2017

1 reference

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Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

20 March 2017

1 reference

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White matter plasticity and enhanced remyelination in the maternal CNS

20 March 2017

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Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein

20 March 2017

1 reference

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SMN interacts with a novel family of hnRNP and spliceosomal proteins

20 March 2017

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The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1

20 March 2017

1 reference

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A functional interaction between the survival motor neuron complex and RNA polymerase II

20 March 2017

1 reference

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Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins

20 March 2017

1 reference

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Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3

20 March 2017

1 reference

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Population frequencies of inherited neuromuscular diseases—A world survey

20 March 2017

1 reference

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Identification and characterization of a spinal muscular atrophy-determining gene

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Digital necroses and vascular thrombosis in severe spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy

29 September 2017

1 reference

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RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Vascular perfusion abnormalities in infants with spinal muscular atrophy

29 September 2017

1 reference

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Pathogenesis of proximal autosomal recessive spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Stat5 constitutive activation rescues defects in spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

29 September 2017

1 reference

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A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

29 September 2017

1 reference

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Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMNT and SMNC gene copy number

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy

29 September 2017

1 reference

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The neuroprotective factor Wld(s) fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Genomic Variation and Gene Conversion in Spinal Muscular Atrophy: Implications for Disease Process and Clinical Phenotype

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Prolactinomas: diagnosis and treatment

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

STAT5A/B activity is required in the developing forebrain and spinal cord.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148738

Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q

27 November 2018

1 reference

12 December 2020

Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid

1 reference

12 December 2020

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

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12 December 2020

Spinal muscular atrophy and therapeutic prospects

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12 December 2020

Genetic therapy for spinal muscular atrophy

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12 December 2020

Recombinant human prolactin for the treatment of lactation insufficiency.

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12 December 2020

From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models

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Prolactin (PRL)-PRL receptor system increases cell proliferation involving JNK (c-Jun amino terminal kinase) and AP-1 activation: inhibition by glucocorticoids

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12 December 2020

Identifiers

DOI

10.1172/JCI46276

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785216%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

8 February 2020

587254

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

587254

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785216%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

21785216

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785216%20AND%20SRC:MED&resulttype=core&format=json