Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability (Q28242891)

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scientific article (publication date: 8 August 2014)

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English	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability	scientific article (publication date: 8 August 2014)

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scholarly article

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21 March 2020

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability (English)

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21 March 2020

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endoplasmic reticulum

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Petra Hyrossova

2

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21 March 2020

Jose C. Perales

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21 March 2020

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Andrés Méndez-Lucas

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21 March 2020

Laura Novellasdemunt

3

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21 March 2020

Francesc Viñals

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21 March 2020

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27 June 2014

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21 March 2020

Journal of Biological Chemistry

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21 March 2020

289

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21 March 2020

32

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21 March 2020

22090-22102

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21 March 2020

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

1 reference

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PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis

1 reference

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

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Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

1 reference

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Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

1 reference

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Cancer cell metabolism: Warburg and beyond

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On the Origin of Cancer Cells

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20 March 2017

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Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

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A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

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Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

20 March 2017

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

20 March 2017

Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase

1 reference

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20 March 2017

The unfolded protein response: from stress pathway to homeostatic regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

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The mammalian unfolded protein response

1 reference

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

7 April 2017

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

29 September 2017

A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

29 September 2017

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

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p73 regulates serine biosynthesis in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

29 September 2017

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

29 September 2017

Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

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ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4139223

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

1 reference

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Resurgence of serine: an often neglected but indispensable amino Acid

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

1 reference

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

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10.1074/JBC.M114.566927

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Consolidated OpenCitations Corpus – April 2017

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21 March 2020

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Consolidated OpenCitations Corpus – April 2017

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2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973213%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973213%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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