The c-Rel transcription factor and B-cell proliferation: a deal with the devil (Q28241767)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14755244%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

review article

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title

The c-Rel transcription factor and B-cell proliferation: a deal with the devil (English)

1 reference

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17 November 2019

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17 November 2019

Thomas D Gilmore

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17 November 2019

Demetrios Kalaitzidis

series ordinal

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17 November 2019

Daniel T Starczynowski

series ordinal

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17 November 2019

language of work or name

English

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publication date

1 March 2004

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17 November 2019

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17 November 2019

volume

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17 November 2019

issue

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17 November 2019

page(s)

2275-2286

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c-Rel is a selective activator of a novel IL-4/CD40 responsive element in the human Ig gamma4 germline promoter.

17 November 2019

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Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

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Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway

21 January 2018

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

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The pathogenetic role of oncogenes deregulated by chromosomal translocation in B-cell malignancies.

21 January 2018

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Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells

21 January 2018

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A switch in distinct I kappa B alpha degradation mechanisms mediates constitutive NF-kappa B activation in mature B cells

21 January 2018

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Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

21 January 2018

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Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

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Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

21 January 2018

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Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer

21 January 2018

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Stable expression of the avian retroviral oncoprotein v-Rel in avian, mouse, and dog cell lines

21 January 2018

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Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

21 January 2018

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The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

21 January 2018

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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

21 January 2018

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Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.

21 January 2018

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

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Syk deficiency--a knockout for B-cell development

21 January 2018

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

21 January 2018

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NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells

21 January 2018

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PU.1/Spi-B regulation of c-rel is essential for mature B cell survival

21 January 2018

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X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2

21 January 2018

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Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

21 January 2018

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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.

21 January 2018

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Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

21 January 2018

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

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Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

21 January 2018

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Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

21 January 2018

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Characterization of a novel promoter insertion in the c-rel locus

21 January 2018

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Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8.

21 January 2018

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The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway

21 January 2018

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Oncogenic transformation by vrel requires an amino-terminal activation domain

21 January 2018

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NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

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Impaired expansion of mouse B cell progenitors lacking Btk.

21 January 2018

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Defective B cell development and function in Btk-deficient mice

21 January 2018

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Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.

21 January 2018

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Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

21 January 2018

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21 January 2018

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Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

21 January 2018

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Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease

21 January 2018

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Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation

21 January 2018

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Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter

21 January 2018

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Bcl11a is essential for normal lymphoid development

21 January 2018

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Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

21 January 2018

1 reference

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Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha

21 January 2018

1 reference

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Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

21 January 2018

1 reference

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Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines

21 January 2018

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Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation

21 January 2018

1 reference

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Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells

21 January 2018

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NF-kappaB activation by protein kinase C isoforms and B-cell function

21 January 2018

1 reference

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A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel

21 January 2018

1 reference

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Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product

21 January 2018

1 reference

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Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes

21 January 2018

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PI3K in lymphocyte development, differentiation and activation

21 January 2018

1 reference

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Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

1 reference

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Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

21 January 2018

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Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

21 January 2018

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The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

21 January 2018

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Chromosome-mediated alterations of the MYC gene in human cancer.

21 January 2018

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Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity

21 January 2018

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Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors

21 January 2018

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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

21 January 2018

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Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel

21 January 2018

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A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes.

21 January 2018

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The BCL11 gene family: involvement of BCL11A in lymphoid malignancies

21 January 2018

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The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

21 January 2018

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Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6

21 January 2018

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A recombinant murine retrovirus expressing v-rel is cytopathic

21 January 2018

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Lymphoid malignancies: the dark side of B-cell differentiation

21 January 2018

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Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

21 January 2018

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The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain

21 January 2018

1 reference

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Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells

21 January 2018

1 reference

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PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

21 January 2018

1 reference

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Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes

21 January 2018

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The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes

21 January 2018

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Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

21 January 2018

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NF-kappaB regulates the expression of the human complement receptor 2 gene

21 January 2018

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c-Rel is essential for B lymphocyte survival and cell cycle progression.

21 January 2018

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Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridization

21 January 2018

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Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB.

21 January 2018

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Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53

21 January 2018

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

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Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

21 January 2018

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21 January 2018

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Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

21 January 2018

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Tumor Necrosis Factor-α Activation of NF-κB Requires the Phosphorylation of Ser-471 in the Transactivation Domain of c-Rel

21 January 2018

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Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways

21 January 2018

1 reference

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7 January 2021

Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract

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7 January 2021

Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit

1 reference

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7 January 2021

Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells

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7 January 2021

The use of real-time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphoma

1 reference

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7 January 2021

A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase

1 reference

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7 January 2021

Expression profiles of p53-, p16(INK4a)-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells

1 reference

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7 January 2021

An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4

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7 January 2021

Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma

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7 January 2021

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations

1 reference

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7 January 2021

Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed–Sternberg cells of classical Hodgkin's lymphoma?

1 reference

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7 January 2021

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

Localisation of a novel region of recurrent amplification in follicular lymphoma to an approximately 6.8 Mb region of 13q32-33

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207410

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207410

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14755244%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 November 2019

1030871158

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14755244%20AND%20SRC:MED&resulttype=core&format=json