The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains (Q28210369)

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neoplasm protein

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Thanos D. Halazonetis

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author name string

John Bothos

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Monica Venere

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Matthew K. Summers

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Daniel M. Scolnick

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full work available at URL

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English

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publication date

16 October 2003

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open access

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DOI

https://api.crossref.org/works/10.1038/SJ.ONC.1206831

https://www.nature.com/articles/1206831

21 March 2024

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DOI

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7101-7

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cites work

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

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Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptides

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Ubiquitin-mediated proteolysis: biological regulation via destruction

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7 January 2021

Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

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Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

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Chfr defines a mitotic stress checkpoint that delays entry into metaphase

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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae

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The FHA domain is a modular phosphopeptide recognition motif.

21 March 2024

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The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

21 March 2024

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 March 2024

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 March 2024

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Ubiquitin enters the new millennium

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Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

21 March 2024

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Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

21 March 2024

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