MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination (Q28210052)

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

The MDM2 gene amplification database

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

N-end rule specificity within the ubiquitin/proteasome pathway is not an affinity effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

A HECT domain E3 enzyme assembles novel polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

MdmX protects p53 from Mdm2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Constitutive mdmx expression during cell growth, differentiation, and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Functional receptors for vasoactive intestinal peptide in cultured vascular smooth muscle cells from rat aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Site-directed mutagenesis of ubiquitin. Differential roles for arginine in the interaction with ubiquitin-activating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Metal and RNA binding properties of the hdm2 RING finger domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

TPEN, a Zn2+/Fe2+ chelator with low affinity for Ca2+, inhibits lamin assembly, destabilizes nuclear architecture and may independently protect nuclei from apoptosis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200

Hdmx stabilizes Mdm2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208593200