Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors (Q28205169)

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Ching Song

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Andrew L Ko

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Shutsung Liao

The liver X receptor gene team: potential new players in atherosclerosis

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language of work or name

English

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publication date

September 2003

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7-8

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page(s)

685-91

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cites work

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Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors

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A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

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NER, a new member of the gene family encoding the human steroid hormone nuclear receptor

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OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor

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Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

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The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor

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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

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Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

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Role of LXRs in control of lipogenesis

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

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Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels

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Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

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Statins and the risk of dementia

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

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Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

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22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes

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Hypolipidemic effects of selective liver X receptor alpha agonists

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YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

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Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

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NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes

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Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

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Developmental regulation of the expression of genes encoding proteins involved in cholesterol homeostasis

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death

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Regulation of the mevalonate pathway

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Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo

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A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

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Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex.

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Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

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