Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress (Q28144631)

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M R Ariyanayagam

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A H Fairlamb

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R L Krauth-Siegel

How do protozoan parasites survive inside macrophages?

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language of work or name

English

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publication date

February 2000

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published in

Molecular Microbiology

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volume

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issue

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page(s)

542-52

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cites work

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Arsenical-resistant trypanosomes lack an unusual adenosine transporter

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Genetic manipulation of kinetoplastida

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Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

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Tissue sulfhydryl groups

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Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids.

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Metabolism and functions of trypanothione in the Kinetoplastida

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

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Trypanothione is the primary target for arsenical drugs against African trypanosomes

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Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

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Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.

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Active site of trypanothione reductase. A target for rational drug design.

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Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress.

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

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Isolation, Expression, and Regulation of thepgr1 + Gene Encoding Glutathione Reductase Absolutely Required for the Growth of Schizosaccharomyces pombe

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Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p

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Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes.

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Production of homozygous mutant ES cells with a single targeting construct

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A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth

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A Unique Cascade of Oxidoreductases Catalyses Trypanothione-Mediated Peroxide Metabolism in Crithidia fasciculata

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Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle

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Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

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Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi.

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Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

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Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

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Inducible gene expression in trypanosomes mediated by a prokaryotic repressor.

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Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.

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Glutathione reductase-deficient erythrocytes as host cells of malarial parasites

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Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei

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