The ciliary neurotrophic factor and its receptor, CNTFR alpha (Q28144474)

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K D Anderson

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P D Lambert

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G D Yancopoulos

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S J Wiegand

Pharmaceutica acta Helvetiae

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language of work or name

English

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publication date

March 2000

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published in

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volume

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issue

2-3

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page(s)

265-72

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cites work

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A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group

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Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease

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Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor

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Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo

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Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury

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The receptor for ciliary neurotrophic factor

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Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

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Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

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In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex

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Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

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Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activity

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Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease

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Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

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Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor.

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Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice

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Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

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Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

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Signaling mechanisms through gp130: a model of the cytokine system

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Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture.

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Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

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CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

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The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

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Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

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Ciliary neurotrophic factor enhances the survival of Purkinje cells in vitro

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Essential function of LIF receptor in motor neurons

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Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

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Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).

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Trophic protection of motor neurons: clinical potential in motor neuron diseases

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CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death.

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Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

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Disruption of the CNTF gene results in motor neuron degeneration.

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Cytokines and cachexia

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Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing

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A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group

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Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptor

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Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor

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Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines

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Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid

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Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture

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CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction

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Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

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Ciliary neurotrophic factor is an endogenous pyrogen

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Control of Na+, K+-pump activity in dorsal root ganglionic neurons by different neuronotrophic agents

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The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

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A null mutation in the human CNTF gene is not causally related to neurological diseases

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A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury

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The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons

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Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor

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Cytokines affecting survival and differentiation of an astrocyte progenitor cell line

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The CIS family: negative regulators of JAK-STAT signaling

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Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

10812968

1 reference

Consolidated OpenCitations Corpus – April 2017