Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function (Q28137829)

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N Nath

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M Adlam

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S Chellappan

Transcriptional control by E2F

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language of work or name

English

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publication date

10 June 1999

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3501-10

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cites work

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The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

21 January 2018

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Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

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E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo

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Molecular themes in oncogenesis

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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The E2F transcription factor is a cellular target for the RB protein

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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Cell cycle-specific association of E2F with the p130 E1A-binding protein

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Tumor suppressor genes and their roles in breast cancer

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Mutations in breast cancer

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Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

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The cell cycle and the retinoblastoma protein family

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Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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Interaction between human cyclin A and adenovirus E1A-associated p107 protein

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G1 cyclins and control of the cell division cycle in normal and transformed cells

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p107 and p130 Associated Cyclin A Has Altered Substrate Specificity

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

21 January 2018

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A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

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Cell-cycle regulators and cancer

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

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E2F and the molecular mechanisms of early cell-cycle control

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DP and E2F proteins: coordinating transcription with cell cycle progression.

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Inactivation of the retinoblastoma susceptibility gene in human breast cancers

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Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner

21 January 2018

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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Rb interacts with histone deacetylase to repress transcription

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Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer

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Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver

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Prohibitin: potential role in senescence, development, and tumor suppression

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

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Disruption of cell-cycle control by viral oncoproteins

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Cell cycle targets of the DNA tumor viruses

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Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells

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The transcription factor E2F-1 is a downstream target of RB action

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The human prohibitin (PHB) gene family and its somatic mutations in human tumors

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Inhibitors of mammalian G1 cyclin-dependent kinases

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The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

21 January 2018

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Expression and regulation of cyclin genes in breast cancer

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RB kinases and RB-binding proteins: new points of view

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E2F-6, a member of the E2F family that can behave as a transcriptional repressor

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The CBP co-activator stimulates E2F1/DP1 activity

21 January 2018

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E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.

21 January 2018

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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The retinoblastoma protein and cell cycle control

21 January 2018

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

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Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases

21 January 2018

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Modulation of E2F Activity via Signaling through Surface IgM and CD40 Receptors in WEHI-231 B Lymphoma Cells

21 January 2018

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The cellular effects of E2F overexpression

21 January 2018

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7 January 2021

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein

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7 January 2021

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins

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7 January 2021

pRB, p107 and the regulation of the E2F transcription factor

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7 January 2021

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

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7 January 2021

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

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7 January 2021

Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition

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7 January 2021

Prohibitin expression during cellular senescence of human diploid fibroblasts

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7 January 2021

Tumor suppressor genes

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7 January 2021

Cyclins and cyclin-dependent kinases: a biochemical view

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7 January 2021

Cell cycle activity and expression of prohibitin mRNA

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7 January 2021

The ins and outs of RB: coupling gene expression to the cell cycle clock

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7 January 2021

The retinoblastoma gene: role in cell cycle control and cell differentiation

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7 January 2021