The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells (Q28115800)

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Language	Label	Description	Also known as
English	The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells	scientific journal article

Statements

scholarly article

1 reference

PubMed publication ID

4 January 2017

The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells (English)

1 reference

PubMed publication ID

4 January 2017

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telomere length

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Protein kinase, DNA-activated, catalytic subunit

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GOA release 2020-03-11

X-ray repair cross complementing 5

1 reference

GOA release 2020-03-11

X-ray repair cross complementing 6

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GOA release 2020-03-11

double-strand break repair via alternative nonhomologous end joining

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GOA release 2020-03-11

author name string

Brian L. Ruis

1

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PubMed publication ID

4 January 2017

Kazi R. Fattah

2

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PubMed publication ID

4 January 2017

Eric A. Hendrickson

3

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PubMed publication ID

4 January 2017

language of work or name

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publication date

1 October 2008

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PubMed publication ID

4 January 2017

Molecular and Cellular Biology

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PubMed publication ID

4 January 2017

28

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PubMed publication ID

4 January 2017

20

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PubMed publication ID

4 January 2017

6182–6195

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PubMed publication ID

4 January 2017

describes a project that uses

HCT 116 PRKDC(+/-)

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HCT 116 PRKDC(-/-)

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NALM-6 PRKDC(+/-)

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

1 reference

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20 March 2017

Tel2 regulates the stability of PI3K-related protein kinases

1 reference

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Gene targeting in stem cells from individuals with osteogenesis imperfecta

1 reference

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20 March 2017

Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice

1 reference

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20 March 2017

Homologous recombination in DNA repair and DNA damage tolerance

1 reference

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Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

1 reference

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Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells

1 reference

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20 March 2017

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

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DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

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A severe combined immunodeficiency mutation in the mouse

1 reference

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Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

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Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

1 reference

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Mutations to Ku reveal differences in human somatic cell lines

1 reference

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29 September 2017

V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.

1 reference

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Cellular response to etoposide treatment.

1 reference

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DNA double-strand break repair: a relentless hunt uncovers new prey.

1 reference

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Precise hit: adeno-associated virus in gene targeting

1 reference

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Mechanism of DNA double-strand break repair by non-homologous end joining

1 reference

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29 September 2017

The life and death of DNA-PK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

Role of human Ku86 in telomere length maintenance and telomere capping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

The DNA-dependent protein kinase: the director at the end.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

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B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells

1 reference

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29 September 2017

Indecent exposure: when telomeres become uncapped

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

1 reference

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29 September 2017

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

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Connecting chromosomes, crisis, and cancer

1 reference

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Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast.

1 reference

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29 September 2017

Ku86 is essential in human somatic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

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DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

1 reference

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29 September 2017

DNA-PKcs is critical for telomere capping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

1 reference

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29 September 2017

Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

1 reference

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

1 reference

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1 reference

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Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.

1 reference

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1 reference

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Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

1 reference

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Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577426

29 September 2017

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

1 reference

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Hypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle

1 reference

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Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

1 reference

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29 September 2017

Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint

1 reference

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Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20

1 reference

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The terminal DNA structure of mammalian chromosomes

1 reference

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1 reference

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Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1 reference

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1 reference

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Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18710952

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18710952

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18710952

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast Ku as a regulator of chromosomal DNA end structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18710952

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/18710952

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.00355-08

1 reference

PubMed publication ID

4 January 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

PubMed publication ID

4 January 2017

ResearchGate publication ID

0 references

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