Designing chimeric antigen receptors to effectively and safely target tumors (Q28088526)

Current Opinion in Immunology

published in

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9-15

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

cites work

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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

20 March 2017

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20 March 2017

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20 March 2017

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Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma

20 March 2017

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Novel serial positive enrichment technology enables clinical multiparameter cell sorting

20 March 2017

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20 March 2017

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Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

7 April 2017

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Inducible apoptosis as a safety switch for adoptive cell therapy

7 April 2017

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

7 April 2017

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

7 April 2017

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Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNγ.

29 September 2017

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The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

29 September 2017

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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

29 September 2017

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Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

29 September 2017

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Current concepts in the diagnosis and management of cytokine release syndrome

29 September 2017

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Out of the bitter came forth sweet: Activating CD28-dependent co-stimulation via PD-1 ligands.

29 September 2017

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29 September 2017

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Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

29 September 2017

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In vivo discovery of immunotherapy targets in the tumour microenvironment

29 September 2017

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T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

29 September 2017

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Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo

29 September 2017

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PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses

29 September 2017

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Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

29 September 2017

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Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells

29 September 2017

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Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma

29 September 2017

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Engineering T cells for cancer: our synthetic future

29 September 2017

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TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

29 September 2017

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Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

29 September 2017

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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

29 September 2017

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Tumor PD-L1 co-stimulates primary human CD8(+) cytotoxic T cells modified to express a PD1:CD28 chimeric receptor.

29 September 2017

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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

29 September 2017

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Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity

29 September 2017

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Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells

29 September 2017

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IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression

29 September 2017

1 reference

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Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

29 September 2017

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A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

29 September 2017

1 reference

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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Heterogeneous differentiation patterns of individual CD8+ T cells.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Disparate individual fates compose robust CD8+ T cell immunity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397136

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25621840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25621840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.COI.2015.01.002

1 reference

release_fgakgi4odrbotb6b3jrveyd7eq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fgakgi4odrbotb6b3jrveyd7eq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

1 reference

PubMed publication ID

25621840

1 reference