Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View (Q28084254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26517052%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Roberta Filograna

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6 June 2020

Mariano Beltramini

series ordinal

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6 June 2020

Marco Bisaglia

series ordinal

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6 June 2020

language of work or name

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2016

1 reference

Current Neuropharmacology

published in

3 references

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6 June 2020

8 October 2022

2 references

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6 June 2020

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6 June 2020

page(s)

260-271

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Creative Commons Attribution-NonCommercial 3.0 Unported

6 June 2020

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25 April 2019

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11 October 2020

on focus list of Wikimedia project

8 October 2022

ScienceSource

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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

29 September 2017

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Antioxidants as therapies: can we improve on nature?

29 September 2017

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Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

29 September 2017

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Neuroprotective effects of creatine

29 September 2017

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Mitochondria-targeted antioxidants as therapies

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Coenzyme Q--biosynthesis and functions

29 September 2017

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Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease

29 September 2017

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Melatonin MT1 and MT2 receptor expression in Parkinson's disease

29 September 2017

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Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

29 September 2017

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Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q

29 September 2017

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Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

29 September 2017

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Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases

29 September 2017

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Non-motor symptoms in Parkinson's disease

29 September 2017

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Parkinson's disease: genetic versus toxin-induced rodent models

29 September 2017

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Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury

29 September 2017

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Dopamine: 50 years in perspective

29 September 2017

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Reduced oxidative damage in ALS by high-dose enteral melatonin treatment

29 September 2017

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Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

29 September 2017

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Toxin-induced models of Parkinson's disease

29 September 2017

1 reference

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Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

29 September 2017

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PINK1 mutations are associated with sporadic early-onset parkinsonism

29 September 2017

1 reference

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Novel chelators for central nervous system disorders that involve alterations in the metabolism of iron and other metal ions.

29 September 2017

1 reference

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

29 September 2017

1 reference

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Glutathione, iron and Parkinson's disease

29 September 2017

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Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence.

29 September 2017

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Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

29 September 2017

1 reference

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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

29 September 2017

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Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species

29 September 2017

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Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

29 September 2017

1 reference

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Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

29 September 2017

1 reference

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A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

29 September 2017

1 reference

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Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes.

29 September 2017

1 reference

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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

29 September 2017

1 reference

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

29 September 2017

1 reference

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Oxidative stress in Parkinson's disease

29 September 2017

1 reference

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Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

29 September 2017

1 reference

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Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group

29 September 2017

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A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease

29 September 2017

1 reference

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Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease

29 September 2017

1 reference

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Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

29 September 2017

1 reference

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Melatonin or silymarin reduces maneb‐ and paraquat‐induced Parkinson’s disease phenotype in the mouse

29 September 2017

1 reference

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Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

2 June 2018

1 reference

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Brain gamma-glutamyl cysteine synthetase (GCS) mRNA expression patterns correlate with regional-specific enzyme activities and glutathione levels

2 June 2018

1 reference

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Increased Protein Oxidation in Human Substantia Nigra Pars Compacta in Comparison with Basal Ganglia and Prefrontal Cortex Measured with an Improved Dinitrophenylhydrazine Assay

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

2 June 2018

1 reference

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Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

2 June 2018

1 reference

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Oxidative stress and Parkinson's disease.

2 June 2018

1 reference

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Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).

2 June 2018

1 reference

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Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

2 June 2018

1 reference

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

2 June 2018

1 reference

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Mitochondrial complex I deficiency in Parkinson's disease

2 June 2018

1 reference

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The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons

2 June 2018

1 reference

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Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine

2 June 2018

1 reference

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Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson's-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses.

27 November 2018

1 reference

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Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease.

27 November 2018

1 reference

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Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

24-Hour variation in gene expression of redox pathway enzymes in rat hypothalamus: effect of melatonin treatment.

27 November 2018

1 reference

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Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Neuroprotective effects of resveratrol on MPTP-induced neuron loss mediated by free radical scavenging

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin for sleep disturbances in Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin fails to protect against long-term MPTP-induced dopamine depletion in mouse striatum

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Protective effect of melatonin in a chronic experimental model of Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin enters the cerebrospinal fluid through the pineal recess

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Chronic administration of pharmacological levels of melatonin does not ameliorate the MPTP-induced degeneration of the nigrostriatal pathway

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Creatine and cyclocreatine attenuate MPTP neurotoxicity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Rhythms of glutathione peroxidase and glutathione reductase in brain of chick and their inhibition by light

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Melatonin is protective against MPTP-induced striatal and hippocampal lesions

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Vitamin E supplements fail to protect mice from acute MPTP neurotoxicity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4857623

Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinsonʼs disease

27 November 2018

1 reference

12 December 2020

Clinical research. Testing a novel strategy against Parkinson's disease

1 reference

12 December 2020

Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Parkinson Study Group

1 reference

12 December 2020

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

12 December 2020

Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease

1 reference

12 December 2020

Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease

1 reference

12 December 2020

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

1 reference

12 December 2020

Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease

1 reference

12 December 2020

THE BIOCHEMISTRY OF DESFERRIOXAMINE AND ITS RELATION TO IRON METABOLISM

1 reference

12 December 2020

Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats

1 reference

12 December 2020

Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial

1 reference

12 December 2020

Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

The effect of coenzyme Q10 therapy in Parkinson disease could be symptomatic

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

10.2174/1570159X13666151030102718

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26517052%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26517052%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26517052%20AND%20SRC:MED&resulttype=core&format=json