CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses (Q28072933)

title

CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses (English)

1 reference

1 reference

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5 June 2020

author name string

Bhushan Dharmadhikari

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5 June 2020

Nur Sharalyn Abdullah

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5 June 2020

Sakthi Rajendran

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5 June 2020

Nur Diana Ishak

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5 June 2020

Emily Nickles

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5 June 2020

Zulkarnain Harfuddin

2 references

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5 June 2020

Herbert Schwarz

2 references

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5 June 2020

language of work or name

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11 November 2015

1 reference

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5 June 2020

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5 June 2020

2 references

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5 June 2020

page(s)

e1113367

2 references

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A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

5 June 2020

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CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers

20 March 2017

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CD137 induces proliferation and endomitosis in monocytes

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Characterisation of soluble murine CD137 and its association with systemic lupus

20 March 2017

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NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

20 March 2017

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29 September 2017

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29 September 2017

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Inhibition of 4-1BBL-regulated TLR response in macrophages ameliorates endotoxin-induced sepsis in mice

29 September 2017

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Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy

29 September 2017

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Targeting CD137 enhances the efficacy of cetuximab.

29 September 2017

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Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy

29 September 2017

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4-1BB chimeric antigen receptors

29 September 2017

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4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy

29 September 2017

1 reference

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CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses

29 September 2017

1 reference

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Dendritic cells, inflammation, and breast cancer

29 September 2017

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CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

29 September 2017

1 reference

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Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

29 September 2017

1 reference

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CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction

29 September 2017

1 reference

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Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways

29 September 2017

1 reference

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Role of 4-1BB receptor in the control played by CD8(+) T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+) T Cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

29 September 2017

1 reference

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Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent

29 September 2017

1 reference

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Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137-mediated immunotherapy for allergic asthma

29 September 2017

1 reference

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The pathophysiology of chronic graft-versus-host disease

29 September 2017

1 reference

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Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.

29 September 2017

1 reference

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CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice

29 September 2017

1 reference

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Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137 stimulation enhances the vaccinal effect of anti-tumor antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Costimulatory TNFR family members in control of viral infection: outstanding questions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

CD137 ligand signaling enhances myelopoiesis during infections

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839363

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

2 June 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Role of 4-1BB in Allograft Rejection Mediated by CD8+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

CD137 ligand signaling induces human monocyte to dendritic cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

4-1BB-mediated immunotherapy of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Anti-4-1BB-based immunotherapy for autoimmune diabetes: lessons from a transgenic non-obese diabetic (NOD) model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F2162402X.2015.1113367

CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling

21 January 2018

1 reference

12 December 2020

CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response

1 reference

12 December 2020

4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms

1 reference

12 December 2020

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

1 reference

12 December 2020

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1 reference

12 December 2020

Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease

1 reference

12 December 2020

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

1 reference

12 December 2020

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

1 reference

12 December 2020

Development of experimental autoimmune encephalomyelitis critically depends on CD137 ligand signaling

1 reference

12 December 2020

A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates

1 reference

12 December 2020

Identification of CD137 as a potent monocyte survival factor

1 reference

12 December 2020

Role of endogenous 4-1BB in the development of systemic lupus erythematosus

1 reference

12 December 2020

Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases

1 reference

12 December 2020

CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells

1 reference

12 December 2020

CD137‐Mediated T Cell Co‐Stimulation Terminates Existing Autoimmune Disease in SLE‐Prone NZB/NZW F1 Mice

1 reference

12 December 2020

Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation

1 reference

12 December 2020

10.1080/2162402X.2015.1113367

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27141396%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27141396%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27141396%20AND%20SRC:MED&resulttype=core&format=json