Emerging metrology for high-throughput nanomaterial genotoxicology (Q28078427)

8 January 2018

review article

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title

Emerging metrology for high-throughput nanomaterial genotoxicology (English)

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8 January 2018

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8 January 2018

Christopher M Sims

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Yuko Ibuki

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8 January 2018

Maria Moreno-Villanueva

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8 January 2018

Giel Hendriks

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8 January 2018

Neenu Singh

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8 January 2018

Bryant C Nelson

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8 January 2018

Christa W Wright

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8 January 2018

language of work or name

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26 August 2016

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8 January 2018

published in

Mutagenesis

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8 January 2018

volume

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8 January 2018

issue

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8 January 2018

page(s)

215-232

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8 January 2018

Emergence of micronuclei as a genomic biomarker

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2 June 2018

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High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology

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2 June 2018

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Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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A comparative performance test of standard, medium- and high-throughput comet assays

2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles

2 June 2018

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The comet assay in nanotoxicology research

2 June 2018

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Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA.

2 June 2018

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Single cell trapping and DNA damage analysis using microwell arrays

2 June 2018

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In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay

2 June 2018

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Upconversion nanoparticles in biological labeling, imaging, and therapy

2 June 2018

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The ability of the high-throughput comet assay to measure the sensitivity of five cell lines toward methyl methanesulfonate, hydrogen peroxide, and pentachlorophenol

2 June 2018

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Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin

2 June 2018

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Automated analysis of DNA damage in the high-throughput version of the comet assay

2 June 2018

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Twelve-gel slide format optimised for comet assay and fluorescent in situ hybridisation

2 June 2018

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gammaH2AX: a sensitive molecular marker of DNA damage and repair

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

In vitro investigations of glycidamide-induced DNA lesions in mouse male germ cells and in mouse and human lymphocytes

2 June 2018

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Development of in vitro systems for nanotoxicology: methodological considerations

2 June 2018

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Understanding biophysicochemical interactions at the nano-bio interface

2 June 2018

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NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

2 June 2018

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8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis

2 June 2018

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Confounding experimental considerations in nanogenotoxicology

2 June 2018

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Cytotoxicity and genotoxicity of silver nanoparticles in human cells

2 June 2018

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Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties

2 June 2018

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2 June 2018

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Growth arrest and DNA damage-45 alpha (GADD45alpha).

2 June 2018

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Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

2 June 2018

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Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Evaluation of the Litron In Vitro MicroFlow Kit for the flow cytometric enumeration of micronuclei (MN) in mammalian cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

The comet assay: topical issues.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a flow cytometric light scatter analysis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Genetic toxicity assessment: employing the best science for human safety evaluation part III: the comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

The NCI60 human tumour cell line anticancer drug screen

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

High-specificity and high-sensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Toxic potential of materials at the nanolevel

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Biomarkers in risk assessment of asbestos exposure

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Oxidative DNA damage and disease: induction, repair and significance

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

The comet assay for DNA damage and repair: principles, applications, and limitations

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Oxidative DNA damage: mechanisms, mutation, and disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Measurement of 8-hydroxy-2'-deoxyguanosine in DNA by high-performance liquid chromatography-mass spectrometry: comparison with measurement by gas chromatography-mass spectrometry

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Fluorometric analysis of DNA unwinding (FADU) as a method for detecting repair-induced DNA strand breaks in UV-irradiated mammalian cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Megabase chromatin domains involved in DNA double-strand breaks in vivo

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Flow cytometric analysis of micronuclei found in cells after irradiation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

A simple technique for quantitation of low levels of DNA damage in individual cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Application of alkaline unwinding assay for detection of mutagen-induced DNA strand breaks

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Use of Cause-and-Effect Analysis to Design a High-Quality Nanocytotoxicology Assay.

2 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Genotoxicity of engineered nanomaterials: A critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

High-throughput comet assay using 96 minigels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Performance of the comet assay in a high-throughput version

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Automatic analysis of silver-stained comets by CellProfiler software.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

A critique of methods to measure cytotoxicity in mammalian cell genotoxicity assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Comet Assay measurements: a perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Can standard genotoxicity tests be applied to nanoparticles?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Miniaturized flow cytometry‐based CHO‐K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Flow cytometric evaluation of the contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

GADD45a-GFP GreenScreen HC assay results for the ECVAM recommended lists of genotoxic and non-genotoxic chemicals for assessment of new genotoxicity tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

The BlueScreen-384 assay as an indicator of genotoxic hazard potential in early-stage drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Real-time size discrimination and elemental analysis of gold nanoparticles using ES-DMA coupled to ICP-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Measurements of nanomaterials in environmentally relevant water matrices using liquid nebulization/differential mobility analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

High-throughput analysis of DNA interstrand crosslinks in human peripheral blood mononuclear cells by automated reverse FADU assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEW037

Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Sensitivity and variability of visual scoring in the comet assay. Results of an inter-laboratory scoring exercise with the use of silver staining

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500194

Nanotechnology. Can high-speed tests sort out which nanomaterials are safe?

27 November 2018

1 reference

12 December 2020

Application of capillary gas chromatography-mass spectrometry to chemical characterization of radiation-induced base damage of DNA: implications for assessing DNA repair processes

1 reference

12 December 2020

The role of nanobiotechnology in the development of personalized medicine

1 reference

12 December 2020

Highly sensitive diagnostic assay for the detection of protein biomarkers using microresonators and multifunctional nanoparticles

1 reference

12 December 2020

Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis

1 reference

12 December 2020

Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay

1 reference

12 December 2020

Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by a flow cytometric in vitro micronucleus assay

1 reference

12 December 2020

Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation

1 reference

12 December 2020

The comet assay: a method to measure DNA damage in individual cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/MUTAGE/GEW037

1 reference

8 January 2018

PMC publication ID

5500194

1 reference

8 January 2018

PubMed publication ID

27565834

1 reference

8 January 2018