Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle (Q27935652)

1 December 2016

title

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle (English)

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PubMed publication ID

21170051

Peptidylprolyl isomerase CPR6 YLR216C

1 December 2016

main subject

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Hsp90 family chaperone HSP82 YPL240C

GOA release 2020-03-11

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Hsp90 cochaperone STI1 YOR027W

GOA release 2020-03-11

1 reference

Nature Structural & Molecular Biology

GOA release 2020-03-11

Klaus Richter

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Jing Li

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Johannes Buchner

series ordinal

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language of work or name

English

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publication date

January 2011

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published in

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Hsp90: a specialized but essential protein-folding tool

PubMed publication ID

1 December 2016

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61-6

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cites work

1 reference

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21 April 2017

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Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties

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Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

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21 April 2017

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hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures

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HSP90: the Rosetta stone for cellular protein dynamics?

21 January 2018

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Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

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Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine

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Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs

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Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

21 January 2018

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Heat-shock protein 90, a chaperone for folding and regulation

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Steroid receptor interactions with heat shock protein and immunophilin chaperones

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The Hsp90 chaperone machinery

21 January 2018

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Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling

21 January 2018

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Enzymes that catalyse the restructuring of proteins

21 January 2018

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Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

21 January 2018

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Reduced levels of hsp90 compromise steroid receptor action in vivo

21 January 2018

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Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes

21 January 2018

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p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity

21 January 2018

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The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

21 January 2018

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Nucleotide-dependent interaction of Saccharomyces cerevisiae Hsp90 with the cochaperone proteins Sti1, Cpr6, and Sba1.

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Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

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NUTS and BOLTS: applications of fluorescence-detected sedimentation

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21 January 2018

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21 January 2018

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The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle

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The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

21 January 2018

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21 January 2018

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Boundary analysis in sedimentation transport experiments: a procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

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FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity

31 March 2020

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The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

31 March 2020

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Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

31 March 2020

1 reference

A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains

31 March 2020

1 reference

Binding of p23 and hsp90 during assembly with the progesterone receptor

31 March 2020

1 reference

12 December 2020

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23

1 reference

12 December 2020

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events

1 reference

12 December 2020

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes

1 reference

12 December 2020

Purification of the major mammalian heat shock proteins

1 reference

12 December 2020

The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies

1 reference

12 December 2020

HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP.

1 reference

12 December 2020