Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria (Q27861937)

GeneDB

10 September 2018

Plasmodium falciparum

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D S Peterson

D S

Peterson

1 reference

21 October 2023

D Walliker

series ordinal

author given names

author last names

Walliker

1 reference

21 October 2023

T E Wellems

series ordinal

author given names

T E

author last names

Wellems

1 reference

Proceedings of the National Academy of Sciences of the United States of America

21 October 2023

language of work or name

English

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publication date

December 1988

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published in

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volume

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issue

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page(s)

9114-8

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cites work

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Human malaria parasites in continuous culture

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Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

20 March 2017

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Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

20 March 2017

1 reference

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Mechanism of pyrimethamine resistance in recent isolates of plasmodium falciparum

29 September 2017

1 reference

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Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

29 September 2017

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Gene amplification in cultured animal cells

29 September 2017

1 reference

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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

29 September 2017

1 reference

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Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum

29 September 2017

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Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

29 September 2017

1 reference

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Comparative Studies on Dihydrofolate Reductases fromPlasmodium falciparumandAotus trivirgatus*

29 September 2017

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Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

29 September 2017

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Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests

2 June 2018

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Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding

2 June 2018

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Clonal diversity in a single isolate of the malaria parasite Plasmodium falciparum

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Drug Sensitivity and Isoenzyme Type in Cloned Lines of Plasmodium Falciparum

2 June 2018

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Chemotherapy of rodent malaria: transfer of resistance vs mutation

2 June 2018

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2 June 2018

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Genomic amplification with transcript sequencing

2 June 2018

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Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication.

2 June 2018

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2 June 2018

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Long-range restriction maps of Plasmodium falciparum chromosomes: crossingover and size variation among geographically distant isolates

2 June 2018

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A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum

2 June 2018

1 reference

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Altered Dihydrofolate Reductase associated with a Pyrimethamine-resistant Plasmodium berghei berghei produced in a Single Step

2 June 2018

1 reference

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Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum

27 November 2018

1 reference

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Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=282674

Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates

27 November 2018

1 reference

12 December 2020

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo

1 reference

12 December 2020

Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi

1 reference

12 December 2020

Daraprim as an antagonist of folic and folinic acids

1 reference

12 December 2020

Dihydrofolate Reductase from Pyrimethamine-resistant Plasmodium berghei

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.85.23.9114

1 reference

ADS bibcode

1988PNAS...85.9114P

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1 reference

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