The spindle-assembly checkpoint in space and time (Q27860766)

Feedback control of mitosis in budding yeast

31 March 2020

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The spindle checkpoint: structural insights into dynamic signalling

31 March 2020

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The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

31 March 2020

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Budding yeast Cdc20: a target of the spindle checkpoint.

31 March 2020

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Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

31 March 2020

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The anaphase promoting complex/cyclosome: a machine designed to destroy

31 March 2020

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

31 March 2020

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

31 March 2020

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Mad2 transiently associates with an APC/p55Cdc complex during mitosis

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p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

31 March 2020

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Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

31 March 2020

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Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

31 March 2020

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MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

31 March 2020

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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

31 March 2020

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Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner

31 March 2020

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Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae

31 March 2020

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Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

31 March 2020

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The spindle checkpoint requires cyclin-dependent kinase activity

31 March 2020

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Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

31 March 2020

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Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis

31 March 2020

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

31 March 2020

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

31 March 2020

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The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint

31 March 2020

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Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

31 March 2020

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Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

31 March 2020

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Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

31 March 2020

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The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

31 March 2020

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Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

31 March 2020

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Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

31 March 2020

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Rod-Zw10-Zwilch: a key player in the spindle checkpoint

31 March 2020

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Identification of a MAD2-binding protein, CMT2, and its role in mitosis

31 March 2020

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Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

31 March 2020

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Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

31 March 2020

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Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint

31 March 2020

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The reversibility of mitotic exit in vertebrate cells

31 March 2020

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Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint.

31 March 2020

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A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

31 March 2020

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MAP kinase is required for the spindle assembly checkpoint but is dispensable for the normal M phase entry and exit in Xenopus egg cell cycle extracts

31 March 2020

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A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells

31 March 2020

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NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling

31 March 2020

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Getting in and out of mitosis with Polo-like kinase-1.

31 March 2020

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CENP-E as an essential component of the mitotic checkpoint in vitro.

31 March 2020

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Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

31 March 2020

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Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

31 March 2020

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Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

31 March 2020

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Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function

31 March 2020

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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

31 March 2020

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The dynamic kinetochore-microtubule interface

31 March 2020

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Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

31 March 2020

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Spindle checkpoint protein dynamics at kinetochores in living cells.

31 March 2020

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Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells

31 March 2020

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In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics

31 March 2020

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Kinetochore structure and function

31 March 2020

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Preventing fatal destruction: inhibitors of the anaphase-promoting complex in meiosis

31 March 2020

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Structural and mechanical control of mitotic progression

31 March 2020

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Kinetochores, microtubules and the metaphase checkpoint

31 March 2020

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Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast

31 March 2020

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Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae

31 March 2020

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Centromere DNA mutations induce a mitotic delay in Saccharomyces cerevisiae

31 March 2020

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NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae

31 March 2020

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Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

31 March 2020

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Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

31 March 2020

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The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

31 March 2020

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Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint

31 March 2020

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The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

31 March 2020

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Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

31 March 2020

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Identification of a human mitotic checkpoint gene: hsMAD2

31 March 2020

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Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

31 March 2020

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Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

31 March 2020

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Timing and checkpoints in the regulation of mitotic progression

31 March 2020

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The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation

31 March 2020

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Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins

31 March 2020

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Kinetochore localization of spindle checkpoint proteins: who controls whom?

31 March 2020

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Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins

31 March 2020

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Kinetochores: if you build it, they will come

31 March 2020

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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1

31 March 2020

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The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

31 March 2020

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Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

31 March 2020

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Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

31 March 2020

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Temporal and spatial control of cyclin B1 destruction in metaphase

31 March 2020

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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

31 March 2020

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Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

31 March 2020

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Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

31 March 2020

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Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

31 March 2020

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How cells get the right chromosomes

31 March 2020

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The spindle checkpoint: tension versus attachment.

31 March 2020

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Correcting improper chromosome-spindle attachments during cell division

31 March 2020

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Aneuploidy: a matter of bad connections.

31 March 2020

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Attachment and tension in the spindle assembly checkpoint

31 March 2020

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Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

31 March 2020

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The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20.

31 March 2020

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

31 March 2020

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Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1.

31 March 2020

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BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

31 March 2020

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Mitotic regulation of the APC activator proteins CDC20 and CDH1

31 March 2020

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Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast

31 March 2020

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Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

31 March 2020

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Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

31 March 2020

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Evaluating putative mechanisms of the mitotic spindle checkpoint

31 March 2020

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Modeling dual pathways for the metazoan spindle assembly checkpoint

31 March 2020

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The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

31 March 2020

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Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

31 March 2020

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Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

31 March 2020

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The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

31 March 2020

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Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

31 March 2020

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The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

31 March 2020

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The Mad2 spindle checkpoint protein has two distinct natively folded states

31 March 2020

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Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

31 March 2020

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How do so few control so many?

31 March 2020

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The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

31 March 2020

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Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

31 March 2020

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Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores

31 March 2020

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Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

31 March 2020

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The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments

31 March 2020

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Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

31 March 2020

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CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

31 March 2020

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CENP-E function at kinetochores is essential for chromosome alignment.

31 March 2020

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CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells

31 March 2020

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Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

31 March 2020

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Chromosomes can congress to the metaphase plate before biorientation

31 March 2020

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Distinct chromosome segregation roles for spindle checkpoint proteins

31 March 2020

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A dual role for Bub1 in the spindle checkpoint and chromosome congression

31 March 2020

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

31 March 2020

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Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

31 March 2020

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Shugoshin: guardian spirit at the centromere

31 March 2020

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Control of Shugoshin function during fission-yeast meiosis

31 March 2020

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Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint

31 March 2020

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Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint

31 March 2020

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Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization

31 March 2020

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The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes

31 March 2020

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Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

31 March 2020

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Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

31 March 2020

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31 March 2020

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The chromosomal passenger complex: guiding Aurora-B through mitosis

31 March 2020

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The cellular geography of aurora kinases

31 March 2020

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The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

31 March 2020

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The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores

31 March 2020

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Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex

31 March 2020

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Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

31 March 2020

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Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

31 March 2020

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ZW10 links mitotic checkpoint signaling to the structural kinetochore.

31 March 2020

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Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling

31 March 2020

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Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control

31 March 2020

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hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

31 March 2020

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Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension

31 March 2020

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Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores

31 March 2020

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In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis.

31 March 2020

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Global mapping of the yeast genetic interaction network

31 March 2020

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Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

31 March 2020

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Before and after the spindle assembly checkpoint--an APC/C point of view

31 March 2020

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Anaphase inactivation of the spindle checkpoint

31 March 2020

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KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

31 March 2020

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

31 March 2020

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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

31 March 2020

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On the road to cancer: aneuploidy and the mitotic checkpoint

31 March 2020

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Aneuploid colon cancer cells have a robust spindle checkpoint

31 March 2020

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

31 March 2020

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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

31 March 2020

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Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

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Validating Aurora B as an anti-cancer drug target.

31 March 2020

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Aurora-kinase inhibitors as anticancer agents

31 March 2020

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The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins

31 March 2020

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The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

31 March 2020

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The human CENP-A centromeric nucleosome-associated complex

31 March 2020

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Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors.

31 March 2020

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Aurora B is enriched at merotelic attachment sites, where it regulates MCAK.

31 March 2020

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Kinetochore capture and bi-orientation on the mitotic spindle.

31 March 2020

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