The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition (Q27733363)

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English	The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8805515%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition (English)

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19 October 2019

1

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19 October 2019

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R M Stroud

2

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19 October 2019

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1 January 1996

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19 October 2019

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19 October 2019

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19 October 2019

1

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19 October 2019

67-77

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19 October 2019

Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives

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Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones

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Inhibition of thymidylate synthase by glyceraldehyde 3-phosphate

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Irreversible Inhibition of Thymidylate Synthase by Pyridoxine (B6) Analogues

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Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

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Interaction of thymidylate synthase with pyridoxal 5'-phosphate as studied by UV/visible difference spectroscopy and molecular modeling

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Structure-based discovery of inhibitors of thymidylate synthase

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Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines

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Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells

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A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

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The clinical pharmacokinetics of the novel antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717)

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

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Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

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Structural basis for recognition of polyglutamyl folates by thymidylate synthase

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Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases

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Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid

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Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

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Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei

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Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex

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Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

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Atomic structure of thymidylate synthase: target for rational drug design

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7 January 2021

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Crystal structure of Escherichia coli thymidylate synthase with FdUMP and 10-propargyl-5,8-dideazafolate

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7 January 2021

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Posttranscriptional regulation of thymidylate synthase gene expression

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7 January 2021

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Identification of an RNA binding site for human thymidylate synthase

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Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells

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Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.

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Identifiers

10.1016/S0969-2126(96)00010-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8805515%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8805515%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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