Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24) (Q27732023)

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English	Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)	scientific article

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scholarly article

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Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24) (English)

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protein structure

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author name string

D Bossemeyer

1

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R A Engh

2

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V Kinzel

3

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H Ponstingl

4

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R Huber

5

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language of work or name

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publication date

March 1993

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The EMBO Journal

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12

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3

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849-59

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Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase

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20 March 2017

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Atomic structure of the actin:DNase I complex

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

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20 March 2017

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Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

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7 April 2017

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

7 April 2017

Mechanistic Studies of cAMP-Dependent Protein Kinase Action

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

29 September 2017

Structural and Functional Aspects of Domain Motions in Proteins

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29 September 2017

Dicyclohexylcarbodiimide cross-links two conserved residues, Asp-184 and Lys-72, at the active site of the catalytic subunit of cAMP-dependent protein kinase

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29 September 2017

Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src

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29 September 2017

Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistr

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29 September 2017

Association of catalytic and regulatory subunits of cyclic AMP-dependent protein kinase requires a negatively charged side group at a conserved threonine

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29 September 2017

1 Protein kinase classification

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Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit

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29 September 2017

Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5'-adenosine. Identification of a modified lysine residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

29 September 2017

Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3‘:5‘-monophosphate-dependent protein kinase

1 reference

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29 September 2017

Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

29 September 2017

Cyclic AMP-dependent ATPase activity of bovine heart protein kinase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

29 September 2017

Adenosine 3':5'-monophosphate dependent protein kinase from bovine heart. Characterization of the catalytic subunit

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29 September 2017

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase

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29 September 2017

Phosphorylation of histone catalyzed by a bovine brain protein kinase

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29 September 2017

Mg X ATP2-dependent interaction of the inhibitor protein of the cAMP-dependent protein kinase with the catalytic subunit

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2 June 2018

Circular dichroic evidence for an ordered sequence of ligand/binding site interactions in the catalytic reaction of the cAMP-dependent protein kinase

1 reference

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2 June 2018

Isotope partitioning in the adenosine 3',5'-monophosphate dependent protein kinase reaction indicates a steady-state random kinetic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.

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2 June 2018

Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

A mutation in the catalytic subunit of protein kinase A prevents myristylation but does not inhibit biological activity.

1 reference

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2 June 2018

Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: substrate-induced conformational changes

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2 June 2018

Multiple mRNA species code for the catalytic subunit of the cAMP-dependent protein kinase from LLC-PK1 cells. Evidence for two forms of the catalytic subunit

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2 June 2018

Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP.

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2 June 2018

Identification of electrostatic interactions that determine the phosphorylation site specificity of the cAMP-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Specificity of bovine heart protein kinase for the Δ-stereoisomer of the metal-ATP complex

1 reference

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2 June 2018

Nuclear magnetic resonance studies of the conformation of tetraamminecobalt(III)-ATP bound at the active site of bovine heart protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

2 June 2018

Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase.

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19 June 2018

The phosphorylase b to a converting enzyme of rabbit skeletal muscle.

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27 November 2018

Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413283

27 November 2018

Ligand binding site interaction in adenosine cyclic 3',5'-monophosphate dependent protein kinase catalytic subunit: circular dichroic evidence for intramolecular transmission of conformational change

1 reference

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27 November 2018

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: nucleotide binding to the chemically modified catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphotransferase sequence homology

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic subunit of cAMP-dependent protein kinase from bovine heart: several isoforms demonstrated by high resolution focusing in immobilized pH gradient

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noncovalent active site interactions enhance the affinity and control the binding order of reversible inhibitors of the cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitor protein of the cAMP-dependent protein kinase-catalytic subunit interaction. Parameters of complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemical and kinetic studies on the action of the catalytic subunit of bovine cardiac muscle adenosine 3',5'-monophosphate dependent protein kinase using metal ion complexes of ATP beta S

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Near- and far-ultraviolet circular dichroism of the catalytic subunit of adenosine cyclic 5'-monophosphate dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sarcoplasmic reticulum ATPase catalyzes hydrolysis of adenyl-5'-yl imidodiphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8384554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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