Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site (Q27671817)

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English	Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site	scientific article

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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title

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site (English)

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

main subject

crystal structure

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allosteric inhibitor

1 reference

based on heuristic

inferred from title

author

Thomas S. Peat

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2

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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11 February 2020

Janet Newman

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5

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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author name string

David I Rhodes

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1

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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11 February 2020

Nick Vandegraaff

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3

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

Dharshini Jeevarajah

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4

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

John Martyn

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6

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PubMed publication ID

21850718

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11 February 2020

Jonathan A V Coates

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7

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PubMed publication ID

21850718

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11 February 2020

Nicholas J Ede

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8

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

Philip Rea

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9

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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11 February 2020

John J Deadman

series ordinal

10

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stated in

Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

publication date

17 August 2011

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PubMed publication ID

21850718

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11 February 2020

published in

ChemBioChem

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

volume

12

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Europe PubMed Central

PubMed publication ID

21850718

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

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11 February 2020

issue

15

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Europe PubMed Central

PubMed publication ID

21850718

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11 February 2020

page(s)

2311-2315

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PubMed publication ID

21850718

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11 February 2020

cites work

Early emergence of raltegravir resistance mutations in patients receiving HAART salvage regimens

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Crossref

reference URL

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retrieved

21 January 2018

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Cellular co-factors of HIV-1 integration

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https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

An essential role for LEDGF/p75 in HIV integration

1 reference

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reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

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https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Retroviral DNA integration: reaction pathway and critical intermediates

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21 January 2018

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

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Crossref

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https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

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21 January 2018

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

retrieved

21 January 2018

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

retrieved

21 January 2018

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FCBIC.201100350

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21 January 2018

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold.

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Identifiers

DOI

10.1002/CBIC.201100350

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21850718

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 February 2020

PubMed publication ID

21850718

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21850718

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21850718%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 February 2020

ResearchGate publication ID

51579948

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