An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes (Q27670926)

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9 February 2020

title

An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes (English)

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9 February 2020

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Annaleise R. Howard-Jones

9 February 2020

object named as

Annaleise R Howard-Jones

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9 February 2020

Christopher T Walsh

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9 February 2020

Peter J Goldman

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9 February 2020

Katherine S Ryan

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9 February 2020

Michael J Hamill

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9 February 2020

Catherine L Drennan

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9 February 2020

publication date

1 July 2012

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9 February 2020

published in

Chemistry and Biology

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volume

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issue

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page(s)

855-865

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

9 February 2020

cites work

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The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction † , ‡

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The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis

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Crystallography gets the jump on the enzymologists

29 September 2017

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Genetic organization of the biosynthetic gene cluster for the indolocarbazole K-252a in Nonomuraea longicatena JCM 11136.

29 September 2017

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Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora

29 September 2017

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Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

29 September 2017

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Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid

29 September 2017

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Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin‐Dependent Monooxygenases RebC and StaC

2 June 2018

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27 November 2018

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Reliable quality-control methods for protein crystal structures

27 November 2018

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27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.05.016

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9 February 2020

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9 February 2020

PubMed publication ID

22840773

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