Crystal Structures of Lgr4 and Its Complex with R-Spondin1 (Q27679218)

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Kanagalaghatta R Rajashankar

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Dorothea Robev

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Dimitar B Nikolov

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

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publication date

3 September 2013

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1683-9

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

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R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

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The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia

29 September 2017

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R-Spondin proteins: a novel link to beta-catenin activation

29 September 2017

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29 September 2017

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

29 September 2017

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Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation.

27 November 2018

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R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

27 November 2018

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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

27 November 2018

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12 December 2020

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Structural diversity of leucine-rich repeat proteins

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12 December 2020

10.1016/J.STR.2013.07.001

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

23891289

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