Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain (Q27668096)

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Nestor Kamdem

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Silke Radetzki

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Gerd Krause

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

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publication date

1 August 2011

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1411-22

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cites work

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

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Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

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Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain

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Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

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Origin of PDZ (DHR, GLGF) domains

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Druggability indices for protein targets derived from NMR-based screening data

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Targeting protein-protein interactions for cancer therapy

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Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription

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Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

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Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

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PDZ domain proteins of synapses

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Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

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Organization of signaling complexes by PDZ-domain scaffold proteins

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Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

21 January 2018

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Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

21 January 2018

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Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor

21 January 2018

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Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1

21 January 2018

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Identification of proteins interacting with the rat somatostatin receptor subtype 2

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An architectural framework that may lie at the core of the postsynaptic density

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Regulation of dendritic spine morphology and synaptic function by Shank and Homer

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Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family

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Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

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A synaptic trek to autism

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The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation

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The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

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Current strategies for the development of peptide-based anti-cancer therapeutics

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Trojan peptides: the penetratin system for intracellular delivery

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Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

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SMART: a web-based tool for the study of genetically mobile domains

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Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

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Protein production by auto-induction in high density shaking cultures

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PDZ domain binding selectivity is optimized across the mouse proteome

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions

21 January 2018

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Searching protein structure databases with DaliLite v.3

21 January 2018

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A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production

21 January 2018

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Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

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Facilities and methods for the high-throughput crystal structural analysis of human proteins.

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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Phasercrystallographic software

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Refinement of macromolecular structures by the maximum-likelihood method

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SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

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