Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1 (Q27667114)

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scientific article published on March 23, 2011

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English	Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1	scientific article published on March 23, 2011

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title

Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1 (English)

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main subject

hydroxysteroid

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based on heuristic

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author name string

Olivier Venier

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1

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Cécile Pascal

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2

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Alain Braun

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3

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Claudie Namane

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4

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Patrick Mougenot

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5

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Olivier Crespin

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6

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François Pacquet

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7

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Cécile Mougenot

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8

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Catherine Monseau

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9

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Bénédicte Onofri

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10

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Rommel Dadji-Faïhun

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11

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Céline Leger

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12

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Majdi Ben-Hassine

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13

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Thao Van-Pham

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14

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Jean-Luc Ragot

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15

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Christophe Philippo

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16

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Stefan Güssregen

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17

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Christian Engel

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18

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Géraldine Farjot

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19

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Lionel Noah

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20

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Karima Maniani

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Eric Nicolaï

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22

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language of work or name

English

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publication date

15 April 2011

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23 March 2011

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stated in

Europe PubMed Central

PubMed publication ID

21439819

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21439819

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28 November 2024

full work available at URL

https://api.elsevier.com/content/article/PII:S0960894X11003076?httpAccept=text/xml

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Crossref

DOI

10.1016/J.BMCL.2011.02.111

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https://api.crossref.org/works/10.1016/J.BMCL.2011.02.111

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28 November 2024

https://api.elsevier.com/content/article/PII:S0960894X11003076?httpAccept=text/plain

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DOI

10.1016/J.BMCL.2011.02.111

reference URL

https://api.crossref.org/works/10.1016/J.BMCL.2011.02.111

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28 November 2024

published in

Bioorganic & Medicinal Chemistry Letters

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volume

21

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issue

8

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page(s)

2244-51

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cites work

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

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28 November 2024

Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?

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Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target

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10.1016/J.BMCL.2011.02.111

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11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

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Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

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Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

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Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model

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Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins

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Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension

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Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.

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Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

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Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome

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Two asymmetric syntheses of AMG 221, an inhibitor of 11beta-hydroxysteroid dehydrogenase type 1.

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Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

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Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

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Drug Metabolism and Disposition

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Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

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Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles

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Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines

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Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

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DOI

10.1016/J.BMCL.2011.02.111

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PubMed publication ID

21439819

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