Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor (Q27664092)

Epidermal growth factor receptor Dmel_CG10079

GOA release 2020-03-11

1 reference

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

GOA release 2020-03-11

Mark A Lemmon

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Diego Alvarado

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Daryl E Klein

series ordinal

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language of work or name

English

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publication date

20 August 2010

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published in

Cell

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volume

142

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issue

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page(s)

568-79

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

20 March 2017

1 reference

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The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

20 March 2017

1 reference

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The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

20 March 2017

1 reference

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EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

20 March 2017

1 reference

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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

20 March 2017

1 reference

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Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

20 March 2017

1 reference

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Structure of the extracellular region of HER3 reveals an interdomain tether

20 March 2017

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Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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29 September 2017

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An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

20 March 2017

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Epidermal growth factor receptor mutations in lung cancer

20 March 2017

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Spatial control of EGF receptor activation by reversible dimerization on living cells

7 April 2017

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A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

29 September 2017

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ErbB receptors and signaling pathways in cancer

29 September 2017

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Functional selectivity of EGF family peptide growth factors: implications for cancer

29 September 2017

1 reference

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Ligand-induced ErbB receptor dimerization

29 September 2017

1 reference

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Structure-based view of epidermal growth factor receptor regulation

29 September 2017

1 reference

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Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

29 September 2017

1 reference

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Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis

29 September 2017

1 reference

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Regulating the dynamics of EGF receptor signaling in space and time

29 September 2017

1 reference

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A structure-based model for ligand binding and dimerization of EGF receptors

29 September 2017

1 reference

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Epidermal growth factor receptor: mechanisms of activation and signalling.

29 September 2017

1 reference

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Structural biology of insulin and IGF1 receptors: implications for drug design

29 September 2017

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High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

29 September 2017

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EGF domain swap converts a drosophila EGF receptor activator into an inhibitor

29 September 2017

1 reference

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Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.

29 September 2017

1 reference

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Two EGF molecules contribute additively to stabilization of the EGFR dimer

29 September 2017

1 reference

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The structural basis of negative cooperativity: receptors and enzymes

29 September 2017

1 reference

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Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro

29 September 2017

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Structure-function relationships for the EGF/TGF-alpha family of mitogens

29 September 2017

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Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

29 September 2017

1 reference

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Allosteric regulation of the epidermal growth factor receptor kinase

29 September 2017

1 reference

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High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Implications of epidermal growth factor (EGF) induced egf receptor aggregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Half-of-the-sites reactivity and conformational states of cytidine triphosphate synthetase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2925043

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

27 November 2018

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells

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12 December 2020

Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number

1 reference

12 December 2020

10.1016/J.CELL.2010.07.015

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

20723758

1 reference