Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus (Q27651991)

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Gary R McLean

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A Louise Creagh

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John W Schrader

X-ray snapshots of the maturation of an antibody response to a protein antigen

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language of work or name

English

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publication date

8 October 2008

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2592-602

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cites work

1 reference

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Antibody multispecificity mediated by conformational diversity

20 March 2017

1 reference

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Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F.

20 March 2017

1 reference

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Structural insights into the evolution of an antibody combining site

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

2 references

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20 March 2017

https://api.crossref.org/works/10.1038/EMBOJ.2008.179

Distinct and opposite diversifying activities of terminal transferase splice variants

22 April 2017

1 reference

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Coupling of local folding to site-specific binding of proteins to DNA

20 March 2017

1 reference

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Autoreactivity of primary human immunoglobulins ancestral to hypermutated human antibodies that neutralize HCMV.

7 April 2017

1 reference

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IMGT-Choreography for immunogenetics and immunoinformatics.

29 September 2017

1 reference

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The evolutionary and structural 'logic' of antigen receptor diversity

29 September 2017

1 reference

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Polyreactivity of antibody molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

A divalent antibody format is required for neutralization of human cytomegalovirus via antigenic domain 2 on glycoprotein B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

The primary antibody repertoire represents a linked network of degenerate antigen specificities

29 September 2017

1 reference

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Toward a comprehensive phylogeny for mammalian and avian herpesviruses

29 September 2017

1 reference

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Polysaccharide vaccines as probes of antibody repertoires in man.

29 September 2017

1 reference

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Repertoire of human antibodies against the polysaccharide capsule of Streptococcus pneumoniae serotype 6B.

29 September 2017

1 reference

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Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Genetic control of early antibody responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Mechanisms of host defense against infection with Streptococcus pneumoniae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

The repertoire of human antibody to the Haemophilus influenzae type b capsular polysaccharide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Positive darwinian selection observed at the variable-region genes of immunoglobulins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

The gp116 of the gp58/116 complex of human cytomegalovirus represents the amino-terminal part of the precursor molecule and contains a neutralizing epitope

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Cell activation by Toll-like receptors: role of LBP and CD14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Recognition of human cytomegalovirus by human primary immunoglobulins identifies an innate foundation to an adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

B‐Cell Abnormalities in AIDS: Stable and Clonally‐Restricted Antibody Response in HIV‐1 Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Passive Immunization during Pregnancy for Congenital Cytomegalovirus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Somatic mutations can lead to a loss of superantigenic and polyreactive binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Evidence for structural plasticity of heavy chain complementarity-determining region 3 in antibody-ssDNA recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.179

Analysis of antibodies of known structure suggests a lack of correspondence between the residues in contact with the antigen and those modified by somatic hypermutation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2567409

Neutralizing mechanisms of two human monoclonal antibodies against human cytomegalovirus glycoprotein 130/55

27 November 2018

1 reference

12 December 2020

Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site

1 reference

12 December 2020

Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response

1 reference

12 December 2020

Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells

1 reference

12 December 2020

Immunotherapy for congenital cytomegalovirus infection

1 reference

12 December 2020

Role of kappa II-A2 light chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b polysaccharide

1 reference

12 December 2020