Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases (Q27658863)

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Yu-Ting Liu

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Robert M Arduini

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Catherine A Hession

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Konrad Miatkowski

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Craig P Wildes

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Patrick F Cullen

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Victor Hong

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Brian T Hopkins

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Elisabeth Mertsching

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Tracy J Jenkins

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Michael J Romanowski

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Darren P Baker

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Laura F Silvian

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc

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publication date

March 2010

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429-39

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cites work

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Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state

20 March 2017

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Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors

20 March 2017

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Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia

20 March 2017

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

20 March 2017

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Searching protein structure databases with DaliLite v.3

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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An approach to multi-copy search in molecular replacement

20 March 2017

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Calculation of protein extinction coefficients from amino acid sequence data

20 March 2017

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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

20 March 2017

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The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

20 March 2017

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Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]

20 March 2017

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Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity

20 March 2017

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

29 September 2017

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Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

29 September 2017

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Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

29 September 2017

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BTKbase: the mutation database for X-linked agammaglobulinemia.

29 September 2017

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Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families

29 September 2017

1 reference

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Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

29 September 2017

1 reference

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The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

29 September 2017

1 reference

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Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.

29 September 2017

1 reference

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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

29 September 2017

1 reference

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X-linked agammaglobulinemia and Bruton's tyrosine kinase.

29 September 2017

1 reference

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The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity

29 September 2017

1 reference

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Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.

27 November 2018

1 reference

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Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

27 November 2018

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12 December 2020

Activation mechanism and steady state kinetics of Bruton's tyrosine kinase

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

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12 December 2020

Identifiers

DOI

10.1002/PRO.321

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PubMed publication ID

20052711

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