Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation (Q27642839)

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Erin J Adams

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Xiao-lin He

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Dar-Chone Chow

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Darcy B Wilson

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K Christopher Garcia

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Mark M Davis

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

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December 2003

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7 January 2021

Distinct molecular mechanisms account for the specificity of two different T-cell receptors

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7 January 2021

A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness.

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7 January 2021

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

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7 January 2021

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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The organizing principle in the formation of the T cell receptor-CD3 complex.

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A new trigger for T cells

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7 January 2021

Ligand recognition by alpha beta T cell receptors

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7 January 2021

Dynamics of Cell Surface Molecules During T Cell Recognition

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7 January 2021

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

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7 January 2021

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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7 January 2021

Structural Basis of Cytochrome c Presentation by IE k

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7 January 2021

Experimental assignment of the structure of the transition state for the association of barnase and barstar

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7 January 2021

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

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7 January 2021

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

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7 January 2021

Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis

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7 January 2021

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

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7 January 2021

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

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7 January 2021

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor

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7 January 2021

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

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7 January 2021

CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

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7 January 2021

Van't Hoff and calorimetric enthalpies from isothermal titration calorimetry: are there significant discrepancies?

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7 January 2021

Ligands for the T-cell receptor: hard times for avidity models

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

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7 January 2021

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

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7 January 2021

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

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Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex

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7 January 2021

PROCHECK: a program to check the stereochemical quality of protein structures

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X-ray snapshots of the maturation of an antibody response to a protein antigen

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7 January 2021

Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.

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7 January 2021

The Human Low Affinity Fcγ Receptors IIa, IIb, and III Bind IgG with Fast Kinetics and Distinct Thermodynamic Properties

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7 January 2021

The basics of binding: mechanisms of antigen recognition and mimicry by antibodies

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7 January 2021

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

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7 January 2021

Predicting binding energetics from structure: looking beyond DeltaG degrees.

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7 January 2021

Structural energetics of peptide recognition: Angiotensin II/antibody binding

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7 January 2021

Energetics of the HIV gp120-CD4 binding reaction

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7 January 2021

A piston model for transmembrane signaling of the aspartate receptor

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Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

Thermodynamic and Kinetic Characterization of the Binding of the TATA Binding Protein to the Adenovirus E4 Promoter

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7 January 2021

The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5

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7 January 2021

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

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7 January 2021

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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7 January 2021

The specificity of TCR/pMHC interaction

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7 January 2021

A kinetic basis for T cell receptor repertoire selection during an immune response

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7 January 2021

Coupling of local folding to site-specific binding of proteins to DNA

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7 January 2021

A structural basis for immunodominant human T cell receptor recognition

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7 January 2021

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

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7 January 2021

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

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7 January 2021

The TCR triggering puzzle

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7 January 2021

Molecular interactions mediating T cell antigen recognition

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7 January 2021

Structural insights into the evolution of an antibody combining site

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7 January 2021

The T-cell receptor signalosome: a dynamic structure with expanding complexity

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7 January 2021

TCR binding to peptide-MHC stabilizes a flexible recognition interface

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7 January 2021

Antibody-antigen interactions: new structures and new conformational changes

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7 January 2021

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

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7 January 2021