Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling (Q27640589)

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scientific article (publication date: 4 March 2003)

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Language	Label	Description	Also known as
English	Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling	scientific article (publication date: 4 March 2003)

Statements

instance of

scholarly article

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title

Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling (English)

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main subject

crystal structure

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author

Steven C. Almo

series ordinal

3

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author name string

Xuewu Zhang

series ordinal

1

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Jean-Claude D Schwartz

series ordinal

2

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Stanley G Nathenson

series ordinal

4

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language of work or name

English

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publication date

4 March 2003

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published in

Proceedings of the National Academy of Sciences of the United States of America

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volume

100

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issue

5

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page(s)

2586-91

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cites work

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B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

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B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.

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Processing of X-ray diffraction data collected in oscillation mode

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[25] Protein multiple sequence alignment and flexible pattern matching

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The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

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Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions

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Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

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CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells

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21 January 2018

Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation

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The assembly and stability of MHC class II-(alpha beta)2 superdimers

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12 December 2020

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Identifiers

DOI

10.1073/PNAS.252771499

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ADS bibcode

2003PNAS..100.2586Z

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PMC publication ID

151384

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PubMed publication ID

12606712

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ResearchGate publication ID

8139043

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