Crystal structure of an inactive Akt2 kinase domain (Q27640282)

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Kurt A Morgenstern

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Yan Gu

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Paul Rose

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Huilin Zhao

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Xiaotian Zhu

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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publication date

January 2003

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21-30

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Mechanism of activation and function of protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Regulation of protein kinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

The akt kinase: molecular determinants of oncogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

PIP2 and PIP3: complex roles at the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Salt-induced conformational changes in the catalytic subunit of adenosine 3',5'-phosphate dependent protein kinase. Use for establishing a connection between one sulfhydryl group and the .gamma.-P subsite in the ATP site of this subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Precision targeting of protein kinases. An affinity label that inactivates the cGMP- but not the cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Irreversible inactivation of protein kinase C by a peptide-substrate analog.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Covalent modification of protein kinase C isozymes by the inactivating peptide substrate analog N-biotinyl-Arg-Arg-Arg-Cys-Leu-Arg-Arg-Leu. Evidence that the biotinylated peptide is an active-site affinity label

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Selenocompounds Induce a Redox Modulation of Protein Kinase C in the Cell, Compartmentally Independent from Cytosolic Glutathione: Its Role in Inhibition of Tumor Promotion

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Cancer-Preventive Selenocompounds Induce a Specific Redox Modification of Cysteine-Rich Regions in Ca2+- Dependent Isoenzymes of Protein Kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

The protein kinase resource

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Protein kinase C signaling and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900937-1

7 January 2021

10.1016/S0969-2126(02)00937-1

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12517337

1 reference

Consolidated OpenCitations Corpus – April 2017