The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae (Q27648715)

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Katherine A H Moore

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Catherine J Marsden

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Vilmos Fülöp

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Kevin G Moffat

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J Michael Lord

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Graham Ladds

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Lynne M Roberts

Ricin. Mechanisms of cytotoxicity.

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language of work or name

English

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publication date

November 2007

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published in

FEBS Journal

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volume

274

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issue

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page(s)

5586-99

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cites work

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Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.

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Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol

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Toxin entry: retrograde transport through the secretory pathway

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Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

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Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA.

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Cross-talk between the pathways leading to the induction of apoptosis and the secretion of tumor necrosis factor-alpha in ricin-treated RAW 264.7 cells

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Selection and characterization of ricin toxin A-chain mutations in Saccharomyces cerevisiae

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Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes.

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Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.

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Nucleotide sequence of cloned cDNA coding for preproricin

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Mutagenesis and kinetic analysis of the active site Glu177 of ricin A-chain.

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X-ray structure of recombinant ricin A-chain at 1.8 A resolution

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Accumulating Evidence Suggests That Several AB-Toxins Subvert the Endoplasmic Reticulum-Associated Protein Degradation Pathway To Enter Target Cells

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Mild temperature shock affects transcription of yeast ribosomal protein genes as well as the stability of their mRNAs

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Transcriptional elements involved in the repression of ribosomal protein synthesis

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Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features.

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

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A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

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The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain

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Processing of X-ray diffraction data collected in oscillation mode

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Refinement of macromolecular structures by the maximum-likelihood method

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Improved methods for building protein models in electron density maps and the location of errors in these models

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wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models

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A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

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Improved Fourier coefficients for maps using phases from partial structures with errors

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