MCM DNA helicase complex subunit MCM2 YBL023C (Q27553071)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29469

DNA replication licensing factor Mcm2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29469

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29469

MCM N-terminal domain, protein family

1 reference

MCM OB domain, protein family

1 reference

MCM domain, protein family

1 reference

Mini-chromosome maintenance, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

single-stranded DNA binding

1 reference

8 April 2019

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

DNA replication origin binding

chromatin binding

1 reference

9 May 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

single-stranded DNA helicase activity

1 reference

8 April 2019

The Mcm2-7 complex has in vitro helicase activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

protein binding

12 references

9 May 2019

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Structure of the eukaryotic MCM complex at 3.8 Å

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

A new MCM modification cycle regulates DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

DNA replication origin binding

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

3'-5' DNA helicase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

DNA replication preinitiation complex

cell component

1 reference

9 May 2019

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

cytoplasm

2 references

7 November 2018

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

7 November 2018

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

replication fork protection complex

1 reference

9 May 2019

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

7 November 2018

7 November 2018

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

7 November 2018

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29469&geneProductId=UniProtKB:P29469

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

TAS

CMG complex

1 reference

9 May 2019

The architecture of a eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

8 April 2019

8 April 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

8 April 2019

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

8 April 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

HDA

cytoplasm

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

HDA

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

9 May 2019

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

HDA

MCM complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

3 references

9 May 2019

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

double-strand break repair via break-induced replication

1 reference

8 April 2019

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

cellular response to DNA damage stimulus

1 reference

9 May 2019

Mcm2 phosphorylation and the response to replicative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

mitotic DNA replication initiation

DNA strand elongation involved in DNA replication

2 references

1 reference

9 May 2019

Uninterrupted MCM2-7 function required for DNA replication fork progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

DNA duplex unwinding

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

negative regulation of DNA helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

1 reference

9 May 2019

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

1 reference

8 April 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

double-strand break repair via break-induced replication

DNA unwinding involved in DNA replication

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

mitotic DNA replication initiation

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Mcm2 is a target of regulation by Cdc7–Dbf4 during the initiation of DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29469

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference