Phosphatidylinositol kinase-related protein kinase TOR2 YKL203C (Q27552396)

serine/threonine-protein kinase TOR

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Armadillo-like helical

1 reference

Armadillo-type fold

1 reference

FKBP12-rapamycin binding domain superfamily

1 reference

Tetratricopeptide-like helical domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

PIK-related kinase, FAT family

1 reference

FKBP12-rapamycin binding domain, protein family

1 reference

PIK-related kinase family

1 reference

FATC domain, protein family

1 reference

Domain of unknown function DUF3385, target of rapamycin protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

protein binding

7 references

14 February 2019

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Superoxide anions regulate TORC1 and its ability to bind Fpr1:rapamycin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1-phosphatidylinositol 4-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

protein-containing complex binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

protein serine/threonine kinase activity

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

27 February 2018

27 February 2018

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

27 February 2018

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

protein serine/threonine kinase activity

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

14 February 2019

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

cell component

TORC1 complex

1 reference

27 February 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

fungal-type vacuole membrane

1 reference

14 February 2019

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

vacuole

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

TORC2 complex

1 reference

27 February 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

extrinsic component of cytoplasmic side of plasma membrane

vacuolar membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

nucleus

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

TORC1 complex

TORC2 complex

mitochondrion

positive regulation of endocytosis

HDA

biological process

1 reference

14 February 2019

Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

TOR signaling

3 references

14 February 2019

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

ribosome biogenesis

1 reference

14 February 2019

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

protein phosphorylation

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

14 February 2019

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

signal transduction

1 reference

14 February 2019

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

actin filament reorganization involved in cell cycle

1 reference

14 February 2019

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

cytoskeleton organization

1 reference

14 February 2019

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

establishment or maintenance of actin cytoskeleton polarity

1 reference

14 February 2019

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

regulation of cell growth

1 reference

14 February 2019

TOR, a central controller of cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

negative regulation of autophagy

1 reference

27 February 2018

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

positive regulation of Rho guanyl-nucleotide exchange factor activity

positive regulation of Rho protein signal transduction

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

1 reference

14 February 2019

regulation of cell cycle

1 reference

14 February 2019

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

phosphatidylinositol phosphate biosynthetic process

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

regulation of snRNA pseudouridine synthesis

1 reference

14 February 2019

The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32600&geneProductId=UniProtKB:P32600

1 reference

27 February 2018

negative regulation of autophagy

negative regulation of macroautophagy

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

TORC1 signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32600

has part(s)

PIK-related kinase, FAT

1 reference

Domain of unknown function DUF3385, target of rapamycin protein

1 reference

FATC domain

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

PIK-related kinase

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

FKBP12-rapamycin binding domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference