MCM DNA helicase complex subunit MCM4 YPR019W (Q27549928)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30665

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30665

Nucleic acid-binding, OB-fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30665

MCM N-terminal domain, protein family

1 reference

MCM OB domain, protein family

1 reference

MCM domain, protein family

1 reference

Mini-chromosome maintenance, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

3'-5' DNA helicase activity

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

single-stranded DNA binding

1 reference

14 February 2019

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA helicase activity

1 reference

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

single-stranded DNA helicase activity

DNA replication origin binding

four-way junction helicase activity

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

protein binding

11 references

9 May 2019

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Structure of the eukaryotic MCM complex at 3.8 Å

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

A new MCM modification cycle regulates DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA replication origin binding

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

single-stranded DNA binding

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

3 references

14 February 2019

14 February 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

14 February 2019

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

MCM core complex

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

nuclear replication fork

1 reference

9 May 2019

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA replication preinitiation complex

1 reference

9 May 2019

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

replication fork protection complex

1 reference

9 May 2019

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

nuclear pre-replicative complex

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

TAS

CMG complex

1 reference

9 May 2019

The architecture of a eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

4 references

9 May 2019

9 May 2019

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

MCM complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

3 references

9 May 2019

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

1 reference

9 May 2019

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

double-strand break repair via break-induced replication

1 reference

14 February 2019

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

nuclear DNA replication

1 reference

9 May 2019

A group of interacting yeast DNA replication genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA unwinding involved in DNA replication

DNA strand elongation involved in DNA replication

2 references

1 reference

14 February 2019

Uninterrupted MCM2-7 function required for DNA replication fork progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

double-strand break repair via break-induced replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

DNA strand elongation involved in DNA replication

mitotic DNA replication initiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30665

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference