Nucleoporin GLE1 YDL207W (Q27549901)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12315

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

nuclear pore complex, fungi

0 references

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

enzyme activator activity

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

IGI

14 February 2019

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

translation initiation factor binding

1 reference

27 March 2018

The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

inositol hexakisphosphate binding

1 reference

27 March 2018

Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

phospholipid binding

1 reference

27 March 2018

Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

protein binding

7 references

14 February 2019

The yeast nuclear pore complex: composition, architecture, and transport mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

An RNA-export mediator with an essential nuclear export signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

inositol hexakisphosphate binding

phospholipid binding

translation initiation factor binding

1 reference

27 March 2018

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

nuclear pore

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

14 February 2019

Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

The yeast nuclear pore complex: composition, architecture, and transport mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

nuclear pore cytoplasmic filaments

1 reference

27 March 2018

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

cytoplasm

nuclear pore cytoplasmic filaments

2 references

2 references

mitochondrion

integral component of membrane

HDA

ISM

1 reference

14 January 2019

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

ISM

biological process

mRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

poly(A)+ mRNA export from nucleus

The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

14 February 2019

mRNA export from nucleus

1 reference

27 March 2018

Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

mRNA transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

regulation of translational initiation

1 reference

27 March 2018

The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

1 reference

14 February 2019

regulation of translational termination

1 reference

27 March 2018

Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12315&geneProductId=UniProtKB:Q12315

positive regulation of catalytic activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12315

mRNA export from nucleus

regulation of translational initiation

regulation of translational termination

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Transporter Classification Database ID

1 reference

20 March 2022

1.I.1.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database