Protein kinase MEC1 YBR136W (Q27548640)

Protein kinase-like domain superfamily

1 reference

Armadillo-type fold

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

PIK-related kinase, FAT family

1 reference

PIK-related kinase family

1 reference

FATC domain, protein family

1 reference

UME domain, protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

protein kinase activity

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

7 references

14 February 2019

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

Dpb11 activates the Mec1-Ddc2 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

protein serine/threonine kinase activity

IPI

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

telomere maintenance via recombination

IBA

biological process

1 reference

14 February 2019

Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

DNA damage induced protein phosphorylation

IMP

1 reference

14 February 2019

Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

nucleobase-containing compound metabolic process

IMP

1 reference

14 February 2019

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

A requirement for recombinational repair in Saccharomyces cerevisiae is caused by DNA replication defects of mec1 mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

positive regulation of DNA-dependent DNA replication

IMP

1 reference

14 February 2019

ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

reciprocal meiotic recombination

IEA

1 reference

14 February 2019

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

21 June 2018

Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38111&geneProductId=UniProtKB:P38111

cellular response to DNA damage stimulus

IDA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

IEA

chromatin organization

1 reference

14 February 2019

DNA damage checkpoint signaling

IEA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38111

1 reference

PIK-related kinase, FAT

1 reference

FATC domain

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

PIK-related kinase

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference