MCM DNA helicase complex subunit MCM6 YGL201C (Q27548477)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53091

DNA replication licensing factor Mcm6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53091

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53091

MCM N-terminal domain, protein family

1 reference

MCM OB domain, protein family

1 reference

MCM domain, protein family

1 reference

Mini-chromosome maintenance, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

DNA helicase activity

1 reference

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

single-stranded DNA helicase activity

four-way junction helicase activity

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

DNA replication origin binding

3'-5' DNA helicase activity

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

DNA helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

protein binding

7 references

9 May 2019

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

A new MCM modification cycle regulates DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

DNA replication origin binding

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

single-stranded DNA binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

single-stranded 3'-5' DNA helicase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

nuclear pre-replicative complex

cell component

replication fork protection complex

1 reference

9 May 2019

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

cytoplasm

1 reference

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

14 February 2019

14 February 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

DNA replication preinitiation complex

1 reference

9 May 2019

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

MCM core complex

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

TAS

CMG complex

1 reference

9 May 2019

The architecture of a eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

MCM complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

3 references

9 May 2019

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

DNA unwinding involved in DNA replication

double-strand break repair via break-induced replication

2 references

1 reference

14 February 2019

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

1 reference

14 February 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

1 reference

9 May 2019

DNA strand elongation involved in DNA replication

1 reference

9 May 2019

Uninterrupted MCM2-7 function required for DNA replication fork progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

double-strand break repair via break-induced replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

mitotic DNA replication

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53091

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference