An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate (Q27349222)

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Kori Ortt

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Barbara Birkaya

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Kirsten Smalley

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Satrajit Sinha

Creative Commons CC0 License

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language of work or name

English

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publication date

2009

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e5623

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start time

20 May 2009

1 reference

April 2022 Public Data File from Crossref

copyrighted, dedicated to the public domain by copyright holder

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2680039/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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p63 regulates proliferation and differentiation of developmentally mature keratinocytes

21 March 2017

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 March 2017

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DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck

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p63 Is essential for the proliferative potential of stem cells in stratified epithelia

21 March 2017

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Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

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p63 is the molecular switch for initiation of an epithelial stratification program

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Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice

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p63 protects the female germ line during meiotic arrest

21 March 2017

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DeltaNp63 plays an anti-apoptotic role in ventral bladder development

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Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

21 March 2017

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p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

21 March 2017

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p63 deficiency activates a program of cellular senescence and leads to accelerated aging

21 March 2017

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Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter

21 March 2017

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 March 2017

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p63 is a p53 homologue required for limb and epidermal morphogenesis

21 March 2017

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DeltaNp63 is essential for epidermal commitment of embryonic stem cells.

21 March 2017

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Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

29 September 2017

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p63 in epithelial development

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Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

29 September 2017

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29 September 2017

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Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach

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p63: defining roles in morphogenesis, homeostasis, and neoplasia of the epidermis

29 September 2017

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Control of keratinocyte proliferation and differentiation by p63.

29 September 2017

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Transcriptional control of lung morphogenesis

29 September 2017

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Conflicting roles for p63 in skin development and carcinogenesis

29 September 2017

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Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells

29 September 2017

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A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.

29 September 2017

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Defining the regulatory elements in the proximal promoter of DeltaNp63 in keratinocytes: Potential roles for Sp1/Sp3, NF-Y, and p63.

29 September 2017

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p63 and epithelial biology

29 September 2017

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The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.

29 September 2017

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IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium

29 September 2017

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p63 and the epithelial stem cell: more than status quo?

29 September 2017

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29 September 2017

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Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity

29 September 2017

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Identification and dissection of an enhancer controlling epithelial gene expression in skin

29 September 2017

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Defining the regulatory factors required for epidermal gene expression

29 September 2017

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Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile

29 September 2017

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Expression of terminal differentiation proteins defines stages of mouse mammary gland development.

2 June 2018

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Type II keratins precede type I keratins during early embryonic development

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Differential expression of p63 isoforms in female reproductive organs

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Transgenic mouse models provide new insights into the role of p63 in epidermal development

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Differential expression of p63 isoforms in normal tissues and neoplastic cells

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Programming gene expression in developing epidermis

2 June 2018

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A chromatin immunoprecipitation screen in mouse keratinocytes reveals Runx1 as a direct transcriptional target of DeltaNp63.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

A dominant-negative form of p63 is required for epidermal proliferation in zebrafish.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Conditional gene expression in the respiratory epithelium of the mouse

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680039

Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19461998

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of GATA-3 in epidermis and hair follicle: relationship to p63

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19461998

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0005623

1 reference

ADS bibcode

2009PLoSO...4.5623R

0 references

1 reference

1 reference

PubMed publication ID

19461998

1 reference