Preclinical mouse cancer models: a maze of opportunities and challenges (Q27322080)

26 June 2017

title

Preclinical mouse cancer models: a maze of opportunities and challenges (English)

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26 June 2017

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Chi-Ping Day

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26 June 2017

Glenn Merlino

series ordinal

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26 June 2017

Terry Van Dyke

series ordinal

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26 June 2017

language of work or name

English

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publication date

1 September 2015

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26 June 2017

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26 June 2017

volume

163

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26 June 2017

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26 June 2017

page(s)

39-53

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Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer

26 June 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

28 September 2017

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Setting up a wide panel of patient-derived tumor xenografts of non-small cell lung cancer by improving the preanalytical steps

28 September 2017

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28 September 2017

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The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

28 September 2017

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28 September 2017

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Patient-derived xenograft models: an emerging platform for translational cancer research

28 September 2017

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28 September 2017

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28 September 2017

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Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.

28 September 2017

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Human cancer growth and therapy in immunodeficient mouse models

28 September 2017

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Tackling the cancer stem cells - what challenges do they pose?

28 September 2017

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Advances in patient-derived tumor xenografts: from target identification to predicting clinical response rates in oncology

28 September 2017

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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

28 September 2017

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Patient-derived xenografts for individualized care in advanced sarcoma.

28 September 2017

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Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

28 September 2017

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Immune modulation in cancer with antibodies

28 September 2017

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A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma

28 September 2017

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MC1R is a potent regulator of PTEN after UV exposure in melanocytes

28 September 2017

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28 September 2017

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Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications

28 September 2017

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28 September 2017

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Development of therapeutic combinations targeting major cancer signaling pathways

28 September 2017

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Genetically engineered animal models for in vivo target identification and validation in oncology

28 September 2017

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The evolutionary basis for differences between the immune systems of man, mouse, pig and ruminants.

28 September 2017

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Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

28 September 2017

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Combinatorial drug therapy for cancer in the post-genomic era.

28 September 2017

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28 September 2017

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nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

28 September 2017

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Circumventing cancer drug resistance in the era of personalized medicine

28 September 2017

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High-resolution genetic mapping using the Mouse Diversity outbred population

28 September 2017

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A pipeline for the generation of shRNA transgenic mice

28 September 2017

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Application of proteomics to cancer early detection

28 September 2017

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Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis

28 September 2017

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A rapid and scalable system for studying gene function in mice using conditional RNA interference

28 September 2017

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Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin

28 September 2017

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Sunitinib malate for the treatment of pancreatic neuroendocrine tumors

28 September 2017

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Survival Benefit With Proapoptotic Molecular and Pathologic Responses From Dual Targeting of Mammalian Target of Rapamycin and Epidermal Growth Factor Receptor in a Preclinical Model of Pancreatic Neuroendocrine Carcinogenesis

28 September 2017

1 reference

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Modeling metastasis biology and therapy in real time in the mouse lung.

28 September 2017

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Non-germline genetically engineered mouse models for translational cancer research

28 September 2017

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Genetically engineered mouse models in cancer research

28 September 2017

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Engineering tumors: a tissue engineering perspective in cancer biology

28 September 2017

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Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

28 September 2017

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A history of cancer chemotherapy

28 September 2017

1 reference

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Modelling Myc inhibition as a cancer therapy

28 September 2017

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A mouse to human search for plasma proteome changes associated with pancreatic tumor development

28 September 2017

1 reference

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Enabling personalized cancer medicine through analysis of gene-expression patterns

28 September 2017

1 reference

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Immunological aspects of cancer chemotherapy

28 September 2017

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Modeling tissue morphogenesis and cancer in 3D.

28 September 2017

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Tumor models for efficacy determination

28 September 2017

1 reference

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The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

28 September 2017

1 reference

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The mighty mouse: genetically engineered mouse models in cancer drug development

28 September 2017

1 reference

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Cytochrome P450 humanised mice

28 September 2017

1 reference

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Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer

28 September 2017

1 reference

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Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

28 September 2017

1 reference

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Cancer modeling in the modern era: progress and challenges

28 September 2017

1 reference

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Use of isogenic human cancer cells for high-throughput screening and drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

28 September 2017

1 reference

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Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia

28 September 2017

1 reference

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Human tumor xenografts as model for drug testing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

A co-clinical platform to accelerate cancer treatment optimization.

31 May 2018

1 reference

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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

31 May 2018

1 reference

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Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia

31 May 2018

1 reference

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Predictive, personalized, preventive, participatory (P4) cancer medicine.

31 May 2018

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A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.

28 November 2018

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The Collaborative Cross, a community resource for the genetic analysis of complex traits

28 November 2018

1 reference

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

28 November 2018

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Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

GFP-transfected tumor cells are useful in examining early metastasis in vivo, but immune reaction precludes long-term tumor development studies in immunocompetent mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

Biological diversity in metastatic neoplasms: origins and implications.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

Comparison of tumor response in nude mice and in the patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583714

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

28 November 2018

1 reference

12 December 2020

Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts

1 reference

12 December 2020

Neonatal sunburn and melanoma in mice

1 reference

12 December 2020

Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL

1 reference

12 December 2020

Why we're losing the war on cancer (and how to win it)

1 reference

12 December 2020

Cancer genomics: from discovery science to personalized medicine

1 reference

12 December 2020

10.1016/J.CELL.2015.08.068

Identifiers

DOI

1 reference

OpenCitations bibliographic resource ID

26 June 2017

4354036

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4354036

1 reference