Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations (Q27325479)

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Carla M Roots

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Edward M Bertram

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Tanya L Crockford

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Belinda Whittle

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Michelle M Simon

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Steve D M Brown

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Christopher C Goodnow

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Richard J Cornall

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2013

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e1003219

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start time

31 January 2013

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Initial sequencing and comparative analysis of the mouse genome

21 March 2017

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A method and server for predicting damaging missense mutations

21 March 2017

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The Sequence Alignment/Map format and SAMtools

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Merlin--rapid analysis of dense genetic maps using sparse gene flow trees

21 March 2017

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Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

21 March 2017

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Stampy: a statistical algorithm for sensitive and fast mapping of Illumina sequence reads

21 March 2017

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Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse

21 March 2017

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

21 March 2017

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BEDTools: a flexible suite of utilities for comparing genomic features

7 April 2017

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Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.

7 April 2017

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Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

28 September 2017

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Fine-scale maps of recombination rates and hotspots in the mouse genome

28 September 2017

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Mutation mapping and identification by whole-genome sequencing

28 September 2017

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Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism

28 September 2017

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Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse.

28 September 2017

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Imputation of single-nucleotide polymorphisms in inbred mice using local phylogeny.

28 September 2017

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Mutation discovery in mice by whole exome sequencing

28 September 2017

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Integration of SNP genotyping confidence scores in IBD inference

28 September 2017

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An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.

28 September 2017

1 reference

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Identity-by-descent filtering of exome sequence data for disease-gene identification in autosomal recessive disorders

28 September 2017

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Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis

28 September 2017

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A new standard genetic map for the laboratory mouse

28 September 2017

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ENU mutagenesis, a way forward to understand gene function

28 September 2017

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A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud.

28 September 2017

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Molecular characterization of ENU mouse mutagenesis and archives

28 September 2017

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Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.

28 September 2017

1 reference

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Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis

28 September 2017

1 reference

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Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice

28 September 2017

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A gene-driven ENU-based approach to generating an allelic series in any gene

28 September 2017

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ENU mutagenesis in the mouse: application to human genetic disease

28 September 2017

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A gene-driven approach to the identification of ENU mutants in the mouse

28 September 2017

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Genome-wide ENU mutagenesis to reveal immune regulators

28 September 2017

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Sequence-based analysis of mutagenized mice

28 September 2017

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28 September 2017

Mouse ENU mutagenesis

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Construction of multilocus genetic linkage maps in humans

28 September 2017

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Use of shuttle vectors to study the molecular processing of defined carcinogen-induced DNA damage: mutagenicity of single O4-ethylthymine adducts in HeLa cells

28 September 2017

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In vitroDNA replication implicates O2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents

28 September 2017

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Reducing the exome search space for mendelian diseases using genetic linkage analysis of exome genotypes

28 September 2017

1 reference

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Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

2 June 2018

1 reference

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A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003219

Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003219

A tutorial on hidden Markov models and selected applications in speech recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003219

Effects of ENU dosage on mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003219

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003219

ENU mutagenesis in the mouse electrophoretic specific-locus test, 1. Dose-response relationship of electrophoretically-detected mutations arising from mouse spermatogonia treated with ethylnitrosourea

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23382690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A dose-response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23382690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1003219

1 reference

1 reference

1 reference

PubMed publication ID

23382690

1 reference