JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg? (Q27012572)

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English	JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?	scientific article

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title

JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg? (English)

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author name string

Linda M. Scott

series ordinal

1

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Vivienne I. Rebel

series ordinal

2

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Crossref

language of work or name

English

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stated in

PubMed

publication date

November 2012

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PubMed

published in

American Journal of Hematology

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PubMed

volume

87

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PubMed

issue

11

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page(s)

1028-36

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cites work

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

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JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

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The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

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TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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21 March 2017

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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Mutation in TET2 in myeloid cancers

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7 April 2017

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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7 April 2017

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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7 April 2017

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

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Dnmt3a is essential for hematopoietic stem cell differentiation

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The JAK2 exon 12 mutations: A comprehensive review

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28 September 2017

Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis

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28 September 2017

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

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28 September 2017

L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability

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28 September 2017

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

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28 September 2017

BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia

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28 September 2017

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.

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28 September 2017

The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

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28 September 2017

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

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28 September 2017

BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair

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28 September 2017

Acquired mutations in TET2 are common in myelodysplastic syndromes

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28 September 2017

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

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28 September 2017

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

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28 September 2017

Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders

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28 September 2017

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

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28 September 2017

Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

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28 September 2017

Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden

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28 September 2017

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort.

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28 September 2017

BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts

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28 September 2017

Life expectancy and prognostic factors in the classic BCR/ABL-negative myeloproliferative disorders.

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28 September 2017

Systemic mastocytosis associated with chronic idiopathic myelofibrosis: a distinct subtype of systemic mastocytosis associated with a [corrected] clonal hematological non-mast [corrected] cell lineage disorder carrying the activating point mutations

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28 September 2017

Chromatin structure regulates gene conversion

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28 September 2017

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

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28 September 2017

Chronic myeloid leukaemia as a model of disease evolution in human cancer

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28 September 2017

DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

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28 September 2017

JAK signaling globally counteracts heterochromatic gene silencing

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28 September 2017

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

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28 September 2017

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

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28 September 2017

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

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28 September 2017

Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

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28 September 2017

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

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28 September 2017

On the molecular origins of the chronic myeloproliferative disorders: it all makes sense

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28 September 2017

Some speculations on the myeloproliferative syndromes.

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28 September 2017

Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera

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28 September 2017

Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis.

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28 September 2017

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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28 September 2017

Clonal origin of chronic myelocytic leukemia in man

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28 September 2017

Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level

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28 September 2017

Polycythemia vera: stem-cell and probable clonal origin of the disease

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28 September 2017

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

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31 May 2018

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia

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31 May 2018

A man with concomitant polycythaemia vera and chronic myeloid leukemia: the dynamics of the two disorders

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31 May 2018

Genetic variegation of clonal architecture and propagating cells in leukaemia

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21 January 2018

Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.

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21 January 2018

Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia.

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21 January 2018

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

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21 January 2018

Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F.

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21 January 2018

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

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reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Prevalance of JAK2 V617F and exon 12 mutations in polycythaemia vera

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Mutations of ASXL1 gene in myeloproliferative neoplasms.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Emergence of therapy-unrelated CML on a background of BCR-ABL-negative JAK2V617F-positive chronic idiopathic myelofibrosis

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

The myeloproliferative neoplasm-associated JAK2 46/1 haplotype is not overrepresented in chronic myelogenous leukemia.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population.

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Two novel JAK2 exon 12 mutations in JAK2V617F-negative polycythaemia vera patients

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Myeloproliferative disorders

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1002%2FAJH.23243

retrieved

21 January 2018

Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22641564

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous detection of JAK2 V617F mutation and Bcr-Abl translocation in a patient with chronic myelogenous leukemia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22641564

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNMT3A mutations in myeloproliferative neoplasms

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22641564

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22641564

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1002/AJH.23243

0 references

Fatcat ID

release_5ceqnsh5ffbybisozicpq7rq5e

0 references

PMC publication ID

3479366

1 reference

stated in

PubMed

PubMed publication ID

22641564

1 reference

stated in

PubMed

ResearchGate publication ID

230611409

0 references

 

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